Browsing Duke Faculty Articles by Author "0310382"

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Anti-AIDS Agents 81. Design, Synthesis, and Structure-Activity Relationship Study of Betulinic Acid and Moronic Acid Derivatives as Potent HIV Maturation Inhibitors

Chen, Chin-Ho; Huang, Li (AMER CHEMICAL SOC, 2010)

In our continuing study of triterpene derivatives as potent anti-HIV agents, different C-3 conformationally restricted betulinic acid (BA, 1) derivatives were designed and synthesized in order to explore the conformational ...
Diarylaniline Derivatives as a Distinct Class of HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors

Huang, Li; Chen, Chin-Ho (AMER CHEMICAL SOC, 2010)

By using structure-based drug design and isosteric replacement, diarylaniline and 1,5-diarylbenzene-1,2-diamine derivatives were synthesized and evaluated against wild type HIV-1 and drug-resistant viral strains, resulting ...