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Browsing Duke Faculty Articles by Duke-affiliated Author "Ramanujam, Nimmi"

Now showing items 1-7 of 7

Instrument independent diffuse reflectance spectroscopy

Yu, Bing; Fu, Henry; Ramanujam, Nimmi (Society of Photo-optical Instrumentation Engineers, 2011-01)

Diffuse reflectance spectroscopy with a fiber optic probe is a powerful tool for quantitative tissue characterization and disease diagnosis. Significant systematic errors can arise in the measured reflectance spectra and ...
A low-cost, portable, and quantitative spectral imaging system for application to biological tissues

Fu, Henry L.; Yu, Bing; Lo, Justin Y.; Ramanujam, Nimmi (OPTICAL SOC AMER, 2010)

The ability of diffuse reflectance spectroscopy to extract quantitative biological composition of tissues has been used to discern tissue types in both pre-clinical and clinical cancer studies. Typically, diffuse reflectance ...
Noninvasive monitoring of tissue hemoglobin using UV-VIS diffuse reflectance spectroscopy: a pilot study

Bender, Janelle E.; Yu, Bing; Richards, Lisa; Ramanujam, Nimmi (OPTICAL SOC AMER, 2009)

We conducted a pilot study on 10 patients undergoing general surgery to test the feasibility of diffuse reflectance spectroscopy in the visible wavelength range as a noninvasive monitoring tool for blood loss during surgery. ...
Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins

Bydlon, Torre M.; Kennedy, Stephanie A.; Richards, Lisa; Brown, J. Quincy; Yu, Bing; Junker, Marlee; Ramanujam, Nimmi (OPTICAL SOC AMER, 2010)

As many as 20-70% of patients undergoing breast conserving surgery require repeat surgeries due to a close or positive surgical margin diagnosed post-operatively [1]. Currently there are no widely accepted tools for ...
Portable, Fiber-Based, Diffuse Reflection Spectroscopy (DRS) Systems for Estimating Tissue Optical Properties

Vishwanath, Karthik; Chang, Kevin; Klein, Daniel; Deng, Yu; Chang, Vivide; Phelps, Janelle; Ramanujam, Nimmi (Optical Society of America, 2011-02)

Steady-state diffuse reflection spectroscopy is a well-studied optical technique that can provide a noninvasive and quantitative method for characterizing the absorption and scattering properties of biological tissues. ...
Rapid ratiometric determination of hemoglobin concentration using UV-VIS diffuse reflectance at isosbestic wavelengths

Phelps, Janelle E.; Vishwanath, Karthik; Chang, Vivide T. C.; Ramanujam, Nimmi (OPTICAL SOC AMER, 2010)

We developed a ratiometric method capable of estimating total hemoglobin concentration from optically measured diffuse reflectance spectra. The three isosbestic wavelength ratio pairs that best correlated to total hemoglobin ...
Towards a field-compatible optical Spectroscopic device for cervical cancer screening in resource-limited settings: effects of calibration and pressure

Chang, Vivide; Yu, Bing; Walmer, David Keith; Ramanujam, Nimmi (Optical Society of America, 2011-08)

Quantitative optical spectroscopy has the potential to provide an effective low cost, and portable solution for cervical pre-cancer screening in resource-limited communities. However, clinical studies to validate the use ...