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Browsing Duke Faculty Articles by Duke-affiliated Author "MacAlpine, David Michael"

DukeSpace

Browsing Duke Faculty Articles by Duke-affiliated Author "MacAlpine, David Michael"

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  • Co-Orientation of Replication and Transcription Preserves Genome Integrity
    MacAlpine, David (PUBLIC LIBRARY SCIENCE, 2010)
    In many bacteria, there is a genome-wide bias towards co-orientation of replication and transcription, with essential and/or highly-expressed genes further enriched co-directionally. We previously found that reversing this ...
  • Expression in Aneuploid Drosophila S2 Cells
    Powell, Sara K.; MacAlpine, David (PUBLIC LIBRARY SCIENCE, 2010)
    Extensive departures from balanced gene dose in aneuploids are highly deleterious. However, we know very little about the relationship between gene copy number and expression in aneuploid cells. We determined copy number ...