Browsing Duke Faculty Articles by Author "Garnsey, Michelle R."

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Development of a Strategy for the Asymmetric Synthesis of Polycyclic Polyprenylated Acylphloroglucinols via N-Amino Cyclic Carbamate Hydrazones: Application to the Total Synthesis of (+)-Clusianone

Garnsey, Michelle R.; Lim, Daniel; Yost, Julianne M.; Coltart, Dr Don (AMER CHEMICAL SOC, 2010)

A broadly applicable asymmetric synthetic strategy utilizing N-amino cyclic carbamate alkylation that provides access to the various stereochemical permutations of a common structural motif found in many polycyclic ...
Direct Carbon-Carbon Bond Formation via Reductive Soft Enolization: A Kinetically Controlled syn-Aldol Addition of alpha-Halo Thioesters and Enolizable Aldehydes

Sauer, Scott; Garnsey, Michelle R.; Coltart, Dr Don (AMER CHEMICAL SOC, 2010)

The direct addition of enolizable aldehydes and a-halo thioesters to produce beta-hydroxy thioesters enabled by reductive soft enolization is reported. The transformation is operationally simple and efficient and has the ...
Direct Carbon-Carbon Bond Formation via Soft Enolization: A Biomimetic Asymmetric Mannich Reaction of Phenylacetate Thioesters

Kohler, Mark C.; Yost, Julianne M.; Garnsey, Michelle R.; Coltart, Dr Don (AMER CHEMICAL SOC, 2010)

An asymmetric Mannich reaction of phenylacetate thioesters and sulfonylimines using cinchona alkaloid-based amino (thio)urea catalysts is reported that employs proximity-assisted soft enolization. This approach to enolization ...