Browsing Duke Faculty Articles by Subject "autophagy"

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Effects of neuronal PIK3C3/Vps34 deletion on autophagy and beyond

Wang, Fan (LANDES BIOSCIENCE, 2010)

PIK3C3/Vps34 plays important roles in the endocytic and autophagic pathways, both of which are essential for maintaining neuronal integrity. However, it is unclear how inactivating PIK3C3 may affect neuronal endosomal ...
Localisation and Mislocalisation of the Interferon-Inducible Immunity-Related GTPase, Irgm1 (LRG-47) in Mouse Cells

Taylor, Gregory (PUBLIC LIBRARY SCIENCE, 2010)

Irgm1 (LRG-47) is an interferon-inducible Golgi membrane associated GTPase of the mouse whose disruption causes susceptibility to many different intracellular pathogens. Irgm1 has been variously interpreted as a regulator ...
MYC activity mitigates response to rapamycin in prostate cancer through 4EBP1-mediated inhibition of autophagy

Balakumaran, Dr Bala; Herbert, J. Taylor; Febbo, Phillip (LANDES BIOSCIENCE, 2010)

Cancer cells have evolved exquisitely to ignore both intrinsic and extrinsic cell death signals, and resistance to cell death is a critical challenge facing clinical oncology. Autophagy, the catabolic recycling process ...
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD

Yao, Tso-Pang (LANDES BIOSCIENCE, 2010)

VCP (VCP/p97) is a ubiquitously expressed member of the AAA(+)-ATPase family of chaperone-like proteins that regulates numerous cellular processes including chromatin decondensation, homotypic membrane fusion and ...