Browsing Duke Faculty Articles by Subject "cancer"

Now showing items 1-9 of 9

Epithelial-mesenchymal transitions and hepatocarcinogenesis

Jou, Janice; Diehl, Anna Mae (AMER SOC CLINICAL INVESTIGATION INC, 2010)

Epithelial-mesenchymal transitions (EMTs) are believed to play a role in invasion and metastasis of many types of tumors. In this issue of the JCI, Chen et al. show that a gene that has been associated with aggressive ...
Learning gradients on manifolds

Mukherjee, Sayan (INT STATISTICAL INST, 2010)

A common belief in high-dimensional data analysis is that data are concentrated on a low-dimensional manifold. This motivates simultaneous dimension reduction and regression on manifolds. We provide an algorithm for learning ...
permGPU: Using graphics processing units in RNA microarray association studies

Shterev, Ivo; Jung, Sin-Ho; George, Stephen; Owzar, Kouros (BIOMED CENTRAL LTD, 2010)

Background: Many analyses of microarray association studies involve permutation, bootstrap resampling and cross-validation, that are ideally formulated as embarrassingly parallel computing problems. Given that these analyses ...
Risk communication in clinical trials: A cognitive experiment and a survey

Cheung, Yin Bun; Yong, Yu Fen; Tan, Say Beng (BIOMED CENTRAL LTD, 2010)

Background: A Royal Statistical Society Working Party recently recommended that "Greater use should be made of numerical, as opposed to verbal, descriptions of risk" in first-in-man clinical trials. This echoed the view ...
Role of Mast Cells in Inflammatory Bowel Disease and Inflammation-Associated Colorectal Neoplasia in IL-10-Deficient Mice

Chichlowski, Maciej; Westwood, Greg S.; Abraham, Soman; Hale, Laura (PUBLIC LIBRARY SCIENCE, 2010)

Background: Inflammatory bowel disease (IBD) is hypothesized to result from stimulation of immune responses against resident intestinal bacteria within a genetically susceptible host. Mast cells may play a critical role ...
Size and shape determination of spheroidal scatterers using two-dimensional angle resolved scattering

Giacomelli, Michael (OPTICAL SOC AMER, 2010)

We demonstrate accurate determination of the size and shape of spherical and spheroidal scatterers through inverse analysis of two-dimensional solid-angle and depth resolved backscattered light intensities. Intensity of ...
Stochastic E2F Activation and Reconciliation of Phenomenological Cell-Cycle Models

Lee, Tae J.; You, Lingchong (PUBLIC LIBRARY SCIENCE, 2010)

The transition of the mammalian cell from quiescence to proliferation is a highly variable process. Over the last four decades, two lines of apparently contradictory, phenomenological models have been proposed to account ...
A Strategy To Advance the Evidence Base in Palliative Medicine: Formation of a Palliative Care Research Cooperative Group

Abernethy, Amy; Wheeler, Jane; Zafar, Yousuf (MARY ANN LIEBERT INC, 2010)

Background: Palliative medicine has made rapid progress in establishing its scientific and clinical legitimacy, yet the evidence base to support clinical practice remains deficient in both the quantity and quality of ...
Tissue Type-Specific Expression of the dsRNA-Binding Protein 76 and Genome-Wide Elucidation of Its Target mRNAs

Neplioueva, Valentina; Dobrikova, Elena; Gromeier, Matthias (PUBLIC LIBRARY SCIENCE, 2010)

Background: RNA-binding proteins accompany all steps in the life of mRNAs and provide dynamic gene regulatory functions for rapid adjustment to changing extra-or intracellular conditions. The association of RNA-binding ...