Browsing Duke Faculty Articles by Subject "extracellular-matrix"

Now showing items 1-5 of 5

Chondrogenesis of Adult Stem Cells from Adipose Tissue and Bone Marrow: Induction by Growth Factors and Cartilage-Derived Matrix

Diekman, Brian O.; Rowland, Christopher R.; Guilak, Farshid (MARY ANN LIEBERT INC, 2010)

Objectives: Adipose-derived stem cells (ASCs) and bone marrow-derived mesenchymal stem cells (MSCs) are multipotent adult stem cells with potential for use in cartilage tissue engineering. We hypothesized that these cells ...
Human uterine leiomyoma-derived fibroblasts stimulate uterine leiomyoma cell proliferation and collagen type I production, and activate RTKs and TGF beta receptor signaling in coculture

Walmer, David; Robboy, Stanley (BIOMED CENTRAL LTD, 2010)

Background: Uterine leiomyomas (fibroids) are benign smooth muscle tumors that often contain an excessive extracellular matrix (ECM). In the present study, we investigated the interactions between human uterine leiomyoma ...
Influence of Acellular Natural Lung Matrix on Murine Embryonic Stem Cell Differentiation and Tissue Formation

Wang, Jennifer (MARY ANN LIEBERT INC, 2010)

We report here the first attempt to produce and use whole acellular (AC) lung as a matrix to support development of engineered lung tissue from murine embryonic stem cells (mESCs). We compared the influence of AC lung, ...
Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4

Jiang, Dianhua; Liang, Jiurong; Guo, Rishu; Xie, Ting; Liu, Ningshan; Jung, Yoosun; Meltzer, Dr Eric; Li, Yuejuan; Noble, Paul (AMER SOC CLINICAL INVESTIGATION INC, 2010)

Pulmonary fibrosis is a progressive, dysregulated response to injury culminating in compromised lung function due to excess extracellular matrix production. The heparan sulfate proteoglycan syndecan-4 is important in ...
Ligament-Derived Matrix Stimulates a Ligamentous Phenotype in Human Adipose-Derived Stem Cells

Guilak, Farshid (MARY ANN LIEBERT INC, 2010)

Human adipose stem cells (hASCs) can differentiate into a variety of phenotypes. Native extracellular matrix (e.g., demineralized bone matrix or small intestinal submucosa) can influence the growth and differentiation of ...