Browsing Duke Faculty Articles by Subject "factor-i"

Now showing items 1-2 of 2

Growth Hormone Mitigates against Lethal Irradiation and Enhances Hematologic and Immune Recovery in Mice and Nonhuman Primates

Chen, Benny; Deoliveira, Divino; Spasojevic, Ivan; Sempowski, Gregory; Wang, Xiaojuan; Gesty-Palmer, Diane; Meadows, Sarah K.; Daher, Pamela; Muramoto, Garrett; Chute, Dr John; Chao, Nelson (PUBLIC LIBRARY SCIENCE, 2010)

Medications that can mitigate against radiation injury are limited. In this study, we investigated the ability of recombinant human growth hormone (rhGH) to mitigate against radiation injury in mice and nonhuman primates. ...
Modulation of Heat Shock Transcription Factor 1 as a Therapeutic Target for Small Molecule Intervention in Neurodegenerative Disease

Neef, Dr Daniel; Turski, Michelle L.; Thiele, Dennis (PUBLIC LIBRARY SCIENCE, 2010)

Neurodegenerative diseases such as Huntington disease are devastating disorders with no therapeutic approaches to ameliorate the underlying protein misfolding defect inherent to poly-glutamine (polyQ) proteins. Given the ...