Browsing Duke Faculty Articles by Subject "functional"

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Telomere Disruption Results in Non-Random Formation of De Novo Dicentric Chromosomes Involving Acrocentric Human Chromosomes

Stimpson, Kaitlin M.; Hayden, Karen E.; Sullivan, Beth (PUBLIC LIBRARY SCIENCE, 2010)

Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly ...