Browsing Scholarly Articles by Subject "gene"

Now showing items 1-15 of 15

Adaptive Mixture Modeling Metropolis Methods for Bayesian Analysis of Nonlinear State-Space Models

West, Mike (AMER STATISTICAL ASSOC, 2010)

We describe a strategy for Markov chain Monte Carlo analysis of nonlinear, non-Gaussian state-space models involving batch analysis for inference on dynamic, latent state variables and fixed model parameters. The key ...
An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer

Morse, Michael (AMER SOC CLINICAL INVESTIGATION INC, 2010)

Therapeutic anticancer vaccines are designed to boost patients' immune responses to tumors. One approach is to use a viral vector to deliver antigen to in situ DCs, which then activate tumor-specific T cell and antibody ...
Altered Ultrasonic Vocalization and Impaired Learning and Memory in Angelman Syndrome Mouse Model with a Large Maternal Deletion from Ube3a to Gabrb3

Jiang, Yong-Hui; Zhu, Li (PUBLIC LIBRARY SCIENCE, 2010)

Angelman syndrome (AS) is a neurobehavioral disorder associated with mental retardation, absence of language development, characteristic electroencephalography (EEG) abnormalities and epilepsy, happy disposition, movement ...
Assessment of LD Matrix Measures for the Analysis of Biological Pathway Association

Qin, Xuejun; Hauser, Elizabeth; Crosslin, David R. (BERKELEY ELECTRONIC PRESS, 2010)

Complex diseases will have multiple functional sites, and it will be invaluable to understand the cross-locus interaction in terms of linkage disequilibrium (LD) between those sites (epistasis) in addition to the haplotype-LD ...
CD20 deficiency in humans results in impaired T cell-independent antibody responses

Tedder, Thomas F. (AMER SOC CLINICAL INVESTIGATION INC, 2010)

CD20 was the first B cell differentiation antigen identified, and CD20-specific mAbs are commonly used for the treatment of B cell malignancies and autoantibody-mediated autoimmune diseases. Despite this the role of CD20 ...
Changes in Bni4 localization induced by cell stress in Saccharomyces cerevisiae

Kozubowski, Lukasz (COMPANY OF BIOLOGISTS LTD, 2010)

Septin complexes at the bud neck in Saccharomyces cerevisiae serve as a scaffold for proteins involved in signaling, cell cycle control, and cell wall synthesis. Many of these bind asymmetrically, associating with either ...
A computational screen for site selective A-to-I editing detects novel sites in neuron specific Hu proteins

Furey, Terry (BIOMED CENTRAL LTD, 2010)

Background: Several bioinformatic approaches have previously been used to find novel sites of ADAR mediated A-to-I RNA editing in human. These studies have discovered thousands of genes that are hyper-edited in their ...
Contributions of Mamu-A*01 Status and TRIM5 Allele Expression, But Not CCL3L Copy Number Variation, to the Control of SIVmac251 Replication in Indian-Origin Rhesus Monkeys

Haynes, Barton (PUBLIC LIBRARY SCIENCE, 2010)

CCL3 is a ligand for the HIV-1 co-receptor CCR5. There have recently been conflicting reports in the literature concerning whether CCL3-like gene (CCL3L) copy number variation (CNV) is associated with resistance to HIV-1 ...
Detection of Alternative Splice Variants at the Proteome Level in Aspergillus flavus

Georgianna, D. Ryan (AMER CHEMICAL SOC, 2010)

Identification of proteins from proteolytic peptides or intact proteins plays an essential role in proteomics. Researchers use search engines to match the acquired peptide sequences to the target proteins. However, search ...
Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation

Skene, J H Pate (AMER SOC CLINICAL INVESTIGATION INC, 2010)

The folate pathway plays a crucial role in the regeneration and repair of the adult CNS after injury. Here, we have shown in rodents that such repair occurs at least in part through DNA methylation. In animals with combined ...
Identification and Inhibitory Properties of a Novel Ca2+/Calmodulin Antagonist

Colomer, Josep; Means, Anthony (AMER CHEMICAL SOC, 2010)

We developed a high-throughput yeast-based assay to screen for chemical inhibitors of Ca2+/calmodulin-dependent kinase pathways. After screening two small libraries, we identified the novel antagonist 125-C9, a substituted ...
Interchangeable Domains in the Kdo Transferases of Escherichia coli and Haemophilus influenzae

Chung, Dr Hak Suk; Raetz, Christian R. H. (AMER CHEMICAL SOC, 2010)

Kdo(2)-lipid A, a conserved substructure of lipopolysaccharide, plays critical roles in Gram-negative bacterial survival and interaction with host organisms. Inhibition of Kdo biosynthesis in Escherichia coli results in ...
Porcine Endothelial Cells Cocultured with Smooth Muscle Cells Became Procoagulant In Vitro

Pang, Zhengyu; Niklason, Laura E.; Truskey, George (MARY ANN LIEBERT INC, 2010)

Endothelial cell (EC) seeding represents a promising approach to provide a nonthrombogenic surface on vascular grafts. In this study, we used a porcine EC/smooth muscle cell (SMC) coculture model that was previously developed ...
Quantum dot-based theranostics

Ho, Yi-Ping; Leong, Kam (ROYAL SOC CHEMISTRY, 2010)

Luminescent semiconductor nanocrystals, also known as quantum dots (QDs), have advanced the fields of molecular diagnostics and nanotherapeutics. Much of the initial progress for QDs in biology and medicine has focused on ...
Rare Variants Create Synthetic Genome-Wide Associations

Dickson, Sam; Goldstein, David (PUBLIC LIBRARY SCIENCE, 2010)

Genome-wide association studies (GWAS) have now identified at least 2,000 common variants that appear associated with common diseases or related traits (http://www.genome.gov/gwastudies), hundreds of which have been ...