Browsing Duke Faculty Articles by Subject "immunodeficiency-virus type-1"

Now showing items 1-11 of 11

Comparative Immunogenicity of HIV-1 Clade C Envelope Proteins for Prime/Boost Studies

Montefiori, David (PUBLIC LIBRARY SCIENCE, 2010)

Background: Previous clinical efficacy trials failed to support the continued development of recombinant gp120 (rgp120) as a candidate HIV vaccine. However, the recent RV144 HIV vaccine trial in Thailand showed that a ...
Design, Synthesis, and Evaluation of Diarylpyridines and Diarylanilines as Potent Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

Chen, Chin-Ho (AMER CHEMICAL SOC, 2010)

On the basis of the structures and activities of our previously identified non-nucleoside reverse transcriptase inhibitors (NNRTIs), we designed and synthesized two sets of derivatives, diarylpyridines (A) and diarylanilines ...
Elevation of Intact and Proteolytic Fragments of Acute Phase Proteins Constitutes the Earliest Systemic Antiviral Response in HIV-1 Infection

Gasper-Smith, Nancy; Haynes, Barton (PUBLIC LIBRARY SCIENCE, 2010)

The earliest immune responses activated in acute human immunodeficiency virus type 1 infection (AHI) exert a critical influence on subsequent virus spread or containment. During this time frame, components of the innate ...
Genetic Signatures in the Envelope Glycoproteins of HIV-1 that Associate with Broadly Neutralizing Antibodies

Li, Ming; Tang, Haili; Greene, Kelli; Gao, Hongmei; Montefiori, David (PUBLIC LIBRARY SCIENCE, 2010)

A steady increase in knowledge of the molecular and antigenic structure of the gp120 and gp41 HIV-1 envelope glycoproteins (Env) is yielding important new insights for vaccine design, but it has been difficult to translate ...
Genome-Wide mRNA Expression Correlates of Viral Control in CD4+T-Cells from HIV-1-Infected Individuals

Dang, Kristen; Fellay, Dr Jacques; Heinzen, Erin L.; Feng, Sheng; Shianna, Kevin; Ge, Dr Dongliang; Goldstein, David (PUBLIC LIBRARY SCIENCE, 2010)

There is great interindividual variability in HIV-1 viral setpoint after seroconversion, some of which is known to be due to genetic differences among infected individuals. Here, our focus is on determining, genome-wide, ...
Host Determinants of HIV-1 Control in African Americans

Pelak, Kimberly; Goldstein, David; Walley, Nicole; Fellay, Dr Jacques; Ge, Dr Dongliang; Shianna, Kevin; Gumbs, Curtis; Maia, Jessica; Cronin, Ken (UNIV CHICAGO PRESS, 2010)

We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene ...
The Humoral Response to HIV-1: New Insights, Renewed Focus

Alter, Galit; Moody, Tony (UNIV CHICAGO PRESS, 2010)

During the past 2 decades, significant advances in our understanding of the humoral immune response to human immunodeficiency virus type 1 (HIV-1) infection have been made, yet a tremendous amount of work lies ahead. Despite ...
Magnitude and Breadth of a Nonprotective Neutralizing Antibody Response in an Efficacy Trial of a Candidate HIV-1 gp120 Vaccine

Montefiori, David (UNIV CHICAGO PRESS, 2010)

Background. A candidate vaccine consisting of human immunodeficiency virus type 1 (HIV-1) subunit gp120 protein was found previously to be nonprotective in an efficacy trial (Vax004) despite strong antibody responses against ...
Potent and broad neutralizing activity of a single chain antibody fragment against cell-free and cell-associated HIV-1

Montefiori, David (LANDES BIOSCIENCE, 2010)

Several human monoclonal antibodies (hmAbs) exhibit relatively potent and broad neutralizing activity against HIV-1, but there has not been much success in using them as potential therapeutics. We have previously hypothesized ...
Similar T-Cell Immune Responses Induced by Group M Consensus Env Immunogens with Wild-Type or Minimum Consensus Variable Regions

Gao, Feng (MARY ANN LIEBERT INC, 2010)

Consensus HIV-1 genes can decrease the genetic distances between candidate immunogens and field virus strains. To ensure the functionality and optimal presentation of immunologic epitopes, we generated two group-M consensus ...
Transmission of Single HIV-1 Genomes and Dynamics of Early Immune Escape Revealed by Ultra-Deep Sequencing

Haynes, Barton (PUBLIC LIBRARY SCIENCE, 2010)

We used ultra-deep sequencing to obtain tens of thousands of HIV-1 sequences from regions targeted by CD8+ T lymphocytes from longitudinal samples from three acutely infected subjects, and modeled viral evolution during ...