Browsing Duke Faculty Articles by Subject "immunology"

Now showing items 1-20 of 22

Acute Eosinophilic Pneumonia Secondary to Daptomycin: A Report of Three Cases

Miller, Rebecca; Gray, Alice; LeBlanc, Thomas W.; Sexton, Daniel (UNIV CHICAGO PRESS, 2010)

We describe 3 cases of daptomycin-induced pulmonary toxic effects that are consistent with drug-induced acute eosinophilic pneumonia. Patients presented similarly with dyspnea, cough, hypoxia, and diffuse ground-glass ...
Adenovirus F protein as a delivery vehicle for botulinum B

Staats, Herman (BIOMED CENTRAL LTD, 2010)

Background: Immunization with recombinant carboxyl-terminal domain of the heavy chain (Hc domain) of botulinum neurotoxin (BoNT) stimulates protective immunity against native BoNT challenge. Most studies developing a ...
Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of America

Perfect, John (UNIV CHICAGO PRESS, 2010)

Cryptococcosis is a global invasive mycosis associated with significant morbidity and mortality. These guidelines for its management have been built on the previous Infectious Diseases Society of America guidelines from ...
Detection of Amino-terminal Extracellular Domain of Somatostatin Receptor 2 by Specific Monoclonal Antibodies and Quantification of Receptor Density in Medulloblastoma

Kuan, Chien-Tsun; Wikstrand, Carol J.; McLendon, Roger; Bigner, Darell (MARY ANN LIEBERT INC, 2009)

Somatostatin receptor 2 (SSTR2) is expressed by most medulloblastomas (MEDs). We isolated monoclonal antibodies (MAbs) to the 12-mer (33)QTEPYYDLTSNA(44), which resides in the extracellular domain of the SSTR2 amino terminus, ...
Determinants of Protection among HIV-Exposed Seronegative Persons: An Overview

Goldstein, David (UNIV CHICAGO PRESS, 2010)

Both clinical experience and a growing medical literature indicate that some persons who have been exposed to human immunodeficiency virus (HIV) infection remain uninfected. Although in some instances this may represent ...
Differential Inhibition of Human Immunodeficiency Virus Type 1 in Peripheral Blood Mononuclear Cells and TZM-bl Cells by Endotoxin-Mediated Chemokine and Gamma Interferon Production

Geonnotti, Anthony R.; Bilska, Mira; Yuan, Xing; Montefiori, David (MARY ANN LIEBERT INC, 2010)

Bacterial lipopolysaccharide ( endotoxin) is a frequent contaminant of biological specimens and is also known to be a potent inducer of beta-chemokines and other soluble factors that inhibit HIV-1 infection in vitro. Though ...
Factors Associated with Mortality in Transplant Patients with Invasive Aspergillosis

Alexander, Barbara (UNIV CHICAGO PRESS, 2010)

Background. Invasive aspergillosis (IA) is an important cause of morbidity and mortality in hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT) recipients. The purpose of this study was to evaluate ...
Final Report of the Lyme Disease Review Panel of the Infectious Diseases Society of America

Lantos, Paul (UNIV CHICAGO PRESS, 2010)

In April 2008, the Infectious Diseases Society of America (IDSA) entered into an agreement with Connecticut Attorney General Richard Blumenthal to voluntarily undertake a special review of its 2006 Lyme disease guidelines. ...
Frequency of Occult High-Grade Squamous Intraepithelial Neoplasia and Invasive Cancer within Anal Condylomata in Men Who Have Sex with Men

Proper, JoAnn (UNIV CHICAGO PRESS, 2010)

Human papillomavirus causes anal condylomata, high-grade anal intraepithelial neoplasia, and anal squamous cell cancer. We found high-grade intraepithelial neoplasia or squamous cell cancer in 75 (47%) of 159 HIV-seropositive ...
Global Trends in Typhoid and Paratyphoid Fever

Crump, John (UNIV CHICAGO PRESS, 2010)

Typhoid and paratyphoid fever continue to be important causes of illness and death, particularly among children and adolescents in south-central and Southeast Asia, where enteric fever is associated with poor sanitation ...
Host Determinants of HIV-1 Control in African Americans

Pelak, Kimberly; Goldstein, David; Walley, Nicole; Fellay, Dr Jacques; Ge, Dr Dongliang; Shianna, Kevin; Gumbs, Curtis; Maia, Jessica; Cronin, Ken (UNIV CHICAGO PRESS, 2010)

We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene ...
The Humoral Response to HIV-1: New Insights, Renewed Focus

Alter, Galit; Moody, Tony (UNIV CHICAGO PRESS, 2010)

During the past 2 decades, significant advances in our understanding of the humoral immune response to human immunodeficiency virus type 1 (HIV-1) infection have been made, yet a tremendous amount of work lies ahead. Despite ...
Invasive Fungal Infections among Organ Transplant Recipients: Results of the Transplant-Associated Infection Surveillance Network (TRANSNET)

Alexander, Barbara (UNIV CHICAGO PRESS, 2010)

Background. Invasive fungal infections (IFIs) are a major cause of morbidity and mortality among organ transplant recipients. Multicenter prospective surveillance data to determine disease burden and secular trends are ...
Lessons Learned from the Anaerobe Survey: Historical Perspective and Review of the Most Recent Data (2005-2007)

Harrell, Lizzie J. (UNIV CHICAGO PRESS, 2010)

Background. The rationale and lessons learned through the evolution of the National Survey for the Susceptibility of Bacteroides fragilis Group from its initiation in 1981 through 2007 are reviewed here. The survey was ...
Magnitude and Breadth of a Nonprotective Neutralizing Antibody Response in an Efficacy Trial of a Candidate HIV-1 gp120 Vaccine

Montefiori, David (UNIV CHICAGO PRESS, 2010)

Background. A candidate vaccine consisting of human immunodeficiency virus type 1 (HIV-1) subunit gp120 protein was found previously to be nonprotective in an efficacy trial (Vax004) despite strong antibody responses against ...
Prenatal Protease Inhibitor Use and Risk of Preterm Birth among HIV-Infected Women Initiating Antiretroviral Drugs during Pregnancy

Livingston, Elizabeth (UNIV CHICAGO PRESS, 2010)

Background. Conflicting results have been reported among studies of protease inhibitor (PI) use during pregnancy and preterm birth. Uncontrolled confounding by indication may explain some of the differences among studies. ...
Prospective Surveillance for Invasive Fungal Infections in Hematopoietic Stem Cell Transplant Recipients, 2001-2006: Overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database

Alexander, Barbara (UNIV CHICAGO PRESS, 2010)

Background. The incidence and epidemiology of invasive fungal infections (IFIs), a leading cause of death among hematopoeitic stem cell transplant (HSCT) recipients, are derived mainly from single-institution retrospective ...
Response of the Infectious Diseases Society of America Lyme Disease Review Panel to Johnson and Stricker

Lantos, Paul (UNIV CHICAGO PRESS, 2010)
Safety, Tolerability, and Mechanisms of Antiretroviral Activity of Pegylated Interferon Alfa-2a in HIV-1-Monoinfected Participants: A Phase II Clinical Trial

Thielman, Nathan (UNIV CHICAGO PRESS, 2010)

Background. To our knowledge, the antiviral activity of pegylated interferon alfa-2a has not been studied in participants with untreated human immunodeficiency virus type 1 (HIV-1) infection but without chronic hepatitis ...
Similar T-Cell Immune Responses Induced by Group M Consensus Env Immunogens with Wild-Type or Minimum Consensus Variable Regions

Gao, Feng (MARY ANN LIEBERT INC, 2010)

Consensus HIV-1 genes can decrease the genetic distances between candidate immunogens and field virus strains. To ensure the functionality and optimal presentation of immunologic epitopes, we generated two group-M consensus ...