Browsing Duke Faculty Articles by Subject "knock-out mice"

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Differential Mechanisms of Morphine Antinociceptive Tolerance Revealed in βArrestin-2 Knock-Out Mice

Bohn, Laura M.; Lefkowitz, Robert J.; Caron, Marc G. (Society for Neuroscience, 2002-12)

Morphine induces antinociception by activating μ opioid receptors (μORs) in spinal and supraspinal regions of the CNS. βarrestin-2 (βarr2), a G-protein-coupled receptor-regulating protein, regulates the μOR in vivo. We ...
Enhanced Rewarding Properties of Morphine, but not Cocaine, in βarrestin-2 Knock-Out Mice

Gainetdinov, Raul Radikovich; Sotnikova, Tatyana; Medvedev, Ivan; Lefkowitz, Robert J.; Caron, Marc G. (Society for Neuroscience, 2003-11)

The reinforcing and psychomotor effects of morphine involve opiate stimulation of the dopaminergic system via activation of μ-opioid receptors (μOR). Both μ-opioid and dopamine receptors are members of the G-protein-coupled ...