Browsing Duke Faculty Articles by Subject "malaria parasites"

Now showing items 1-1 of 1

Structure-Based Design and Synthesis of Potent, Ethylenediamine-Based, Mammalian Farnesyltransferase Inhibitors as Anticancer Agents

Hast, Michael; Beese, Lorena (AMER CHEMICAL SOC, 2010)

A potent class of anticancer. human farnesyltransferase (111:Tase) inhibitors has been identified by "piggy-backing" on potent, antimalarial inhibitors of Plosmodium falciparum farnesyltransferase (P/FTase). On the basis ...