Browsing Duke Faculty Articles by Subject "overexpression"

Now showing items 1-2 of 2

Association between DNA Damage Response and Repair Genes and Risk of Invasive Serous Ovarian Cancer

Schildkraut, Joellen; Moorman, Patricia (PUBLIC LIBRARY SCIENCE, 2010)

Background: We analyzed the association between 53 genes related to DNA repair and p53-mediated damage response and serous ovarian cancer risk using case-control data from the North Carolina Ovarian Cancer Study (NCOCS), ...
Expression signatures of TP53 mutations in serous ovarian cancers

Baba, Tsukasa; Lee, Paula S.; Barnett, Jason C.; Sfakianos, Gregory P.; Secord, Angeles; Murphy, Susan; Berchuck, Andrew (BIOMED CENTRAL LTD, 2010)

Background: Mutations in the TP53 gene are extremely common and occur very early in the progression of serous ovarian cancers. Gene expression patterns that relate to mutational status may provide insight into the etiology ...