Browsing Scholarly Articles by Subject "p53"

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Association between DNA Damage Response and Repair Genes and Risk of Invasive Serous Ovarian Cancer

Schildkraut, Joellen; Moorman, Patricia (PUBLIC LIBRARY SCIENCE, 2010)

Background: We analyzed the association between 53 genes related to DNA repair and p53-mediated damage response and serous ovarian cancer risk using case-control data from the North Carolina Ovarian Cancer Study (NCOCS), ...
Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells

Misra, Uma K.; Pizzo, Salvatore (LANDES BIOSCIENCE, 2010)

We have previously shown that treatment of prostate cancer and melanoma cells expressing GRP78 on their cell surface with antibody directed against the COOH-terminal domain of GRP78 upregulates and activates p53 causing ...
Trade-Offs Between Cancer and Other Diseases: Do They Exist and Influence Longevity?

Ukraintseva, Svetlana V.; Arbeev, Konstantin; Akushevich, Igor; Kulminski, Dr Alexander; Arbeeva, Liubov; Culminskaya, Irina; Akushevich, Lucy; Yashin, Anatoliy (MARY ANN LIEBERT INC, 2010)

Relationships between aging, disease risks, and longevity are not yet well understood. For example, joint increases in cancer risk and total survival observed in many human populations and some experimental aging studies ...