Browsing Duke Faculty Articles by Subject "tumor-growth"

Now showing items 1-3 of 3

C. elegans Germline-Deficient Mutants Respond to Pathogen Infection Using Shared and Distinct Mechanisms

TeKippe, Michael; Aballay, Alejandro (PUBLIC LIBRARY SCIENCE, 2010)

Reproduction extracts a cost in resources that organisms are then unable to utilize to deal with a multitude of environmental stressors. In the nematode C. elegans, development of the germline shortens the lifespan of the ...
Human uterine leiomyoma-derived fibroblasts stimulate uterine leiomyoma cell proliferation and collagen type I production, and activate RTKs and TGF beta receptor signaling in coculture

Walmer, David; Robboy, Stanley (BIOMED CENTRAL LTD, 2010)

Background: Uterine leiomyomas (fibroids) are benign smooth muscle tumors that often contain an excessive extracellular matrix (ECM). In the present study, we investigated the interactions between human uterine leiomyoma ...
Latent Factor Analysis to Discover Pathway-Associated Putative Segmental Aneuploidies in Human Cancers

Lucas, Joseph; Kung, Hsiu-Ni; Chi, Jen-Tsan A. (PUBLIC LIBRARY SCIENCE, 2010)

Tumor microenvironmental stresses, such as hypoxia and lactic acidosis, play important roles in tumor progression. Although gene signatures reflecting the influence of these stresses are powerful approaches to link expression ...