Browsing Duke Faculty Articles by Subject "variants"

Now showing items 1-4 of 4

Assessment of LD Matrix Measures for the Analysis of Biological Pathway Association

Qin, Xuejun; Hauser, Elizabeth; Crosslin, David R. (BERKELEY ELECTRONIC PRESS, 2010)

Complex diseases will have multiple functional sites, and it will be invaluable to understand the cross-locus interaction in terms of linkage disequilibrium (LD) between those sites (epistasis) in addition to the haplotype-LD ...
Genome-Wide Scan of Copy Number Variation in Late-Onset Alzheimer's Disease

Heinzen, Erin L. (IOS PRESS, 2010)

Alzheimer's disease is a complex and progressive neurodegenerative disease leading to loss of memory, cognitive impairment, and ultimately death. To date, six large-scale genome-wide association studies have been conducted ...
High Multiplicity Infection by HIV-1 in Men Who Have Sex with Men

Hicks, Charles; Haynes, Barton (PUBLIC LIBRARY SCIENCE, 2010)

Elucidating virus-host interactions responsible for HIV-1 transmission is important for advancing HIV-1 prevention strategies. To this end, single genome amplification (SGA) and sequencing of HIV-1 within the context of a ...
Transmission of Single HIV-1 Genomes and Dynamics of Early Immune Escape Revealed by Ultra-Deep Sequencing

Haynes, Barton (PUBLIC LIBRARY SCIENCE, 2010)

We used ultra-deep sequencing to obtain tens of thousands of HIV-1 sequences from regions targeted by CD8+ T lymphocytes from longitudinal samples from three acutely infected subjects, and modeled viral evolution during ...