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dc.contributor.advisor Hong, Jiyong en_US
dc.contributor.author Kasper, Amanda Clare en_US
dc.date.accessioned 2011-01-06T16:00:33Z
dc.date.available 2012-12-12T05:30:13Z
dc.date.issued 2010 en_US
dc.identifier.uri http://hdl.handle.net/10161/3069
dc.description Dissertation en_US
dc.description.abstract <p>This dissertation focuses on three main projects that include aspects of natural product synthesis, synthetic methodology, as well as the development of a small molecular probe for the study of protein palmitoylation. This first project introduces studies towards the synthesis of manassantins A and B which are potent inhibitors of hypoxia-inducible factor 1 (HIF-1). In addition, the preparation of manassantin A analogues is described along with preliminary structure-activity relationship (SAR) studies providing further insight into the structural requirements for HIF-1 inhibitory activity. The second project describes efforts towards the development of a fluorescence resonance energy transfer (FRET)-based assay system to characterize the palmitoylation of oncogenic Src family kinases. The initial work on this project involves the synthesis of a modified lipopeptide mimicking the critical N-terminus sequence of Src signaling proteins required for activation. Lastly, the third project focuses on the development of an asymmetric organocatalytic method to synthesize 2,7-cis- and 2,7-trans oxepanes as well as its application to the preparation of a simple cyclic ether. Ultimately, the goal of this work would be to extend this methodology to the preparation of complex, biologically active cyclic ethers.</p> en_US
dc.subject Chemistry en_US
dc.subject en_US
dc.title I. Studies Towards the Synthesis of Manassantins A and B and Analogues II. Efforts Towards a FRET-Based Assay to Characterize Palmitoylation of Src Kinases III. Synthesis of Oxepanes via Organocatalytic Oxa-Michael Reactions en_US
dc.type Dissertation en_US
dc.department Chemistry en_US
duke.embargo.months 24 en_US

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