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dc.contributor.advisor Tedder, Thomas F en_US
dc.contributor.author DiLillo, DJ
dc.contributor.author Horikawa, M
dc.contributor.author Tedder, TF
dc.coverage.spatial United States
dc.date.accessioned 2011-01-06T16:01:03Z
dc.date.issued 2011-04
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/21125343
dc.identifier.citation Immunol Res, 2011, 49 (1-3), pp. 281 - 292
dc.identifier.uri http://hdl.handle.net/10161/3077
dc.description Dissertation en_US
dc.description.abstract B-lymphocytes have traditionally been thought to contribute to immunity and autoimmune disease through terminal differentiation into plasma cells that secrete antibody. However, studies in mice and recent clinical studies have demonstrated that genetically altered B-cell function and B-cell-targeted therapies can significantly affect autoimmune diseases that were predominantly thought to be T-cell-mediated. B-cell depletion in mouse models of disease has also led to the identification of alternative B-cell effector functions that regulate normal immune responses and autoimmune disease. This review highlights multiple B-cell effector mechanisms, including the promotion of cellular immunity, the negative regulation of immune responses, and the production of pathogenic antibodies.
dc.format.extent 281 - 292
dc.language eng
dc.relation.ispartof Immunol Res
dc.relation.isversionof 10.1007/s12026-010-8189-3
dc.subject Animals
dc.subject Antibody Formation
dc.subject Autoimmune Diseases
dc.subject B-Lymphocytes
dc.subject Humans
dc.subject Immunity, Cellular
dc.subject Lymphocyte Activation
dc.subject T-Lymphocytes
dc.title B-lymphocyte effector functions in health and disease.
dc.type Journal Article
dc.department Immunology en_US
duke.embargo.months 6 en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/21125343
pubs.issue 1-3
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Immunology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pediatrics
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pediatrics/Pediatrics, Allergy and Immunology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.publication-status Published
pubs.volume 49
dc.identifier.eissn 1559-0755

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