Show simple item record

dc.contributor.advisor Slotkin, Ted en_US
dc.contributor.author Powers, Christina Marie en_US
dc.date.accessioned 2011-01-06T16:03:51Z
dc.date.available 2011-01-06T16:03:51Z
dc.date.issued 2010 en_US
dc.identifier.uri http://hdl.handle.net/10161/3128
dc.description Dissertation en_US
dc.description.abstract <p>Background: Silver nanoparticles (AgNPs) act as antimicrobials by releasing monovalent silver (Ag+) and are increasingly used in consumer products, thus elevating exposures in human and environmental populations. Materials and Methods: We evaluated Ag+ in a standard model of neuronal cell replication and differentiation, and then determined whether there were similar effects of the ion in vivo using zebrafish. Next, we compared Ag+ and AgNP exposures in the same two models and incorporated the effects of particle coating, size and composition. Conclusions: This work is the first to show that both Ag+ and AgNPs are developmental neurotoxicants in vitro and in vivo. Moreover, although both the soluble ion and the particles impair measures of neurodevelopment, the outcomes and underlying mechanisms of each toxicant are often wholly distinct. Superimposed on the dichotomies between Ag+ and AgNP exposures are clear effects of particle coating, size and composition that will necessitate evaluation of individual AgNP types when considering potential environmental and human health effects. The results presented here provide hazard identification that can help isolate the models and endpoints necessary for developing a risk assessment framework for the growing use of AgNPs.</p> en_US
dc.subject Toxicology en_US
dc.subject Environmental Health en_US
dc.subject neurodevelopment en_US
dc.subject PC12 cells en_US
dc.subject silver en_US
dc.subject silver nanoparticles en_US
dc.subject zebrafish en_US
dc.title Developmental Neurotoxicity of Silver and Silver Nanoparticles Modeled In Vitro and In Vivo en_US
dc.type Dissertation en_US
dc.department Pharmacology en_US

Files in this item

This item appears in the following Collection(s)

Show simple item record