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dc.contributor.author Caso, JR
dc.contributor.author Mouraviev, V
dc.contributor.author Tsivian, M
dc.contributor.author Polascik, TJ
dc.contributor.author Moul, JW
dc.coverage.spatial United States
dc.date.accessioned 2011-04-15T16:46:23Z
dc.date.issued 2010-05
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20367442
dc.identifier.citation J Endourol, 2010, 24 (5), pp. 805 - 809
dc.identifier.uri http://hdl.handle.net/10161/3242
dc.description.abstract Since at least the early 1990s, stage and risk migration have been seen in patients with prostate cancer, likely corresponding to the institution of prostate specific antigen (PSA) screening in health systems. Preoperative risk factors, including PSA level and clinical stage, have decreased significantly. These improved prognostic variables have led to a larger portion of men being stratified with low-risk disease, as per the classification of D'Amico and associates. This, in turn, has corresponded with more favorable postoperative variables, including decreased extraprostatic tumor extension and prolonged biochemical-free recurrence rates. The advent of focal therapy is bolstered by findings of increased unilateral disease with decreased tumor volume. Increasingly, targeted or delayed therapies may be possible within the current era of lower risk disease.
dc.format.extent 805 - 809
dc.language ENG
dc.language.iso en_US en_US
dc.relation.ispartof J Endourol
dc.relation.isversionof 10.1089/end.2009.0539
dc.subject Biomarkers, Tumor
dc.subject Humans
dc.subject Male
dc.subject Neoplasm Staging
dc.subject Prostate-Specific Antigen
dc.subject Prostatic Neoplasms
dc.subject Risk Assessment
dc.subject Risk Factors
dc.title Prostate cancer: an evolving paradigm.
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-5-0 en_US
duke.description.endpage 809 en_US
duke.description.issue 5 en_US
duke.description.startpage 805 en_US
duke.description.volume 24 en_US
dc.relation.journal Journal of Endourology en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20367442
pubs.issue 5
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Anesthesiology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Surgery
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Surgery/Surgery, Urology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.publication-status Published
pubs.volume 24
dc.identifier.eissn 1557-900X

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