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dc.contributor.author Ukraintseva, SV
dc.contributor.author Arbeev, KG
dc.contributor.author Akushevich, I
dc.contributor.author Kulminski, A
dc.contributor.author Arbeeva, L
dc.contributor.author Culminskaya, I
dc.contributor.author Akushevich, L
dc.contributor.author Yashin, AI
dc.coverage.spatial United States
dc.date.accessioned 2011-04-15T16:46:35Z
dc.date.issued 2010-08
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20426618
dc.identifier.citation Rejuvenation Res, 2010, 13 (4), pp. 387 - 396
dc.identifier.uri http://hdl.handle.net/10161/3295
dc.description.abstract Relationships between aging, disease risks, and longevity are not yet well understood. For example, joint increases in cancer risk and total survival observed in many human populations and some experimental aging studies may be linked to a trade-off between cancer and aging as well as to the trade-off(s) between cancer and other diseases, and their relative impact is not clear. While the former trade-off (between cancer and aging) received broad attention in aging research, the latter one lacks respective studies, although its understanding is important for developing optimal strategies of increasing both longevity and healthy life span. In this paper, we explore the possibility of trade-offs between risks of cancer and selected major disorders. First, we review current literature suggesting that the trade-offs between cancer and other diseases may exist and be linked to the differential intensity of apoptosis. Then we select relevant disorders for the analysis (acute coronary heart disease [ACHD], stroke, asthma, and Alzheimer disease [AD]) and calculate the risk of cancer among individuals with each of these disorders, and vice versa, using the Framingham Study (5209 individuals) and the National Long Term Care Survey (NLTCS) (38,214 individuals) data. We found a reduction in cancer risk among old (80+) men with stroke and in risk of ACHD among men (50+) with cancer in the Framingham Study. We also found an increase in ACHD and stroke among individuals with cancer, and a reduction in cancer risk among women with AD in the NLTCS. The manifestation of trade-offs between risks of cancer and other diseases thus depended on sex, age, and study population. We discuss factors modulating the potential trade-offs between major disorders in populations, e.g., disease treatments. Further study is needed to clarify possible impact of such trade-offs on longevity.
dc.format.extent 387 - 396
dc.language ENG
dc.language.iso en_US en_US
dc.relation.ispartof Rejuvenation Res
dc.relation.isversionof 10.1089/rej.2009.0941
dc.subject Adult
dc.subject Disease
dc.subject Female
dc.subject Humans
dc.subject Longevity
dc.subject Male
dc.subject Middle Aged
dc.subject Neoplasms
dc.title Trade-offs between cancer and other diseases: do they exist and influence longevity?
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-8-0 en_US
duke.description.endpage 396 en_US
duke.description.issue 4 en_US
duke.description.startpage 387 en_US
duke.description.volume 13 en_US
dc.relation.journal Rejuvenation Research en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20426618
pubs.issue 4
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Social Science Research Institute
pubs.organisational-group /Duke/Sanford School of Public Policy
pubs.organisational-group /Duke/Sanford School of Public Policy/Duke Population Research Institute
pubs.organisational-group /Duke/Sanford School of Public Policy/Duke Population Research Institute/Center for Population Health & Aging
pubs.organisational-group /Duke/Sanford School of Public Policy/Duke Population Research Institute/Duke Population Research Center
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.organisational-group /Duke/Staff
pubs.organisational-group /Duke/Trinity College of Arts & Sciences
pubs.organisational-group /Duke/Trinity College of Arts & Sciences/Physics
pubs.publication-status Published
pubs.volume 13
dc.identifier.eissn 1557-8577

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