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dc.contributor.author Jenista, ER
dc.contributor.author Stokes, AM
dc.contributor.author Branca, RT
dc.contributor.author Warren, WS
dc.coverage.spatial United States
dc.date.accessioned 2011-04-15T16:46:39Z
dc.date.issued 2009-11-28
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/19947697
dc.identifier.citation J Chem Phys, 2009, 131 (20), pp. 204510 - ?
dc.identifier.uri http://hdl.handle.net/10161/3315
dc.description.abstract A recent quantum computing paper (G. S. Uhrig, Phys. Rev. Lett. 98, 100504 (2007)) analytically derived optimal pulse spacings for a multiple spin echo sequence designed to remove decoherence in a two-level system coupled to a bath. The spacings in what has been called a "Uhrig dynamic decoupling (UDD) sequence" differ dramatically from the conventional, equal pulse spacing of a Carr-Purcell-Meiboom-Gill (CPMG) multiple spin echo sequence. The UDD sequence was derived for a model that is unrelated to magnetic resonance, but was recently shown theoretically to be more general. Here we show that the UDD sequence has theoretical advantages for magnetic resonance imaging of structured materials such as tissue, where diffusion in compartmentalized and microstructured environments leads to fluctuating fields on a range of different time scales. We also show experimentally, both in excised tissue and in a live mouse tumor model, that optimal UDD sequences produce different T(2)-weighted contrast than do CPMG sequences with the same number of pulses and total delay, with substantial enhancements in most regions. This permits improved characterization of low-frequency spectral density functions in a wide range of applications.
dc.format.extent 204510 - ?
dc.language ENG
dc.language.iso en_US en_US
dc.relation.ispartof J Chem Phys
dc.relation.isversionof 10.1063/1.3263196
dc.subject Animals
dc.subject Contrast Media
dc.subject Health Care Reform
dc.subject Magnetic Resonance Imaging
dc.subject Magnetic Resonance Spectroscopy
dc.subject Mice
dc.title Optimized, unequal pulse spacing in multiple echo sequences improves refocusing in magnetic resonance.
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2009-11-28 en_US
duke.description.endpage 204510 en_US
duke.description.issue 20 en_US
duke.description.startpage 204510 en_US
duke.description.volume 131 en_US
dc.relation.journal Journal of Chemical Physics en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/19947697
pubs.issue 20
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.organisational-group /Duke/Trinity College of Arts & Sciences
pubs.organisational-group /Duke/Trinity College of Arts & Sciences/Chemistry
pubs.organisational-group /Duke/Trinity College of Arts & Sciences/Physics
pubs.publication-status Published
pubs.volume 131
dc.identifier.eissn 1089-7690

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