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dc.contributor.author Batinić-Haberle, I
dc.contributor.author Rebouças, JS
dc.contributor.author Spasojević, I
dc.coverage.spatial United States
dc.date.accessioned 2011-04-15T16:46:23Z
dc.date.issued 2010-09-15
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20095865
dc.identifier.citation Antioxid Redox Signal, 2010, 13 (6), pp. 877 - 918
dc.identifier.uri http://hdl.handle.net/10161/3344
dc.description.abstract Oxidative stress has become widely viewed as an underlying condition in a number of diseases, such as ischemia-reperfusion disorders, central nervous system disorders, cardiovascular conditions, cancer, and diabetes. Thus, natural and synthetic antioxidants have been actively sought. Superoxide dismutase is a first line of defense against oxidative stress under physiological and pathological conditions. Therefore, the development of therapeutics aimed at mimicking superoxide dismutase was a natural maneuver. Metalloporphyrins, as well as Mn cyclic polyamines, Mn salen derivatives and nitroxides were all originally developed as SOD mimics. The same thermodynamic and electrostatic properties that make them potent SOD mimics may allow them to reduce other reactive species such as peroxynitrite, peroxynitrite-derived CO(3)(*-), peroxyl radical, and less efficiently H(2)O(2). By doing so SOD mimics can decrease both primary and secondary oxidative events, the latter arising from the inhibition of cellular transcriptional activity. To better judge the therapeutic potential and the advantage of one over the other type of compound, comparative studies of different classes of drugs in the same cellular and/or animal models are needed. We here provide a comprehensive overview of the chemical properties and some in vivo effects observed with various classes of compounds with a special emphasis on porphyrin-based compounds.
dc.format.extent 877 - 918
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof Antioxid Redox Signal
dc.relation.isversionof 10.1089/ars.2009.2876
dc.subject Animals
dc.subject Biomimetic Materials
dc.subject Humans
dc.subject Manganese
dc.subject Organometallic Compounds
dc.subject Polyamines
dc.subject Porphyrins
dc.subject Superoxide Dismutase
dc.title Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential.
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-9-0 en_US
duke.description.endpage 918 en_US
duke.description.issue 6 en_US
duke.description.startpage 877 en_US
duke.description.volume 13 en_US
dc.relation.journal Antioxidants & Redox Signaling en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20095865
pubs.issue 6
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Medical Oncology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Radiation Oncology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.publication-status Published
pubs.volume 13
dc.identifier.eissn 1557-7716

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