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dc.contributor.author Hodgkinson, CP
dc.contributor.author Gomez, JA
dc.contributor.author Mirotsou, M
dc.contributor.author Dzau, VJ
dc.coverage.spatial United States
dc.date.accessioned 2011-04-15T16:46:30Z
dc.date.issued 2010-11
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20825283
dc.identifier.citation Hum Gene Ther, 2010, 21 (11), pp. 1513 - 1526
dc.identifier.uri http://hdl.handle.net/10161/3377
dc.description.abstract The use of stem cells for tissue regeneration and repair is advancing both at the bench and bedside. Stem cells isolated from bone marrow are currently being tested for their therapeutic potential in a variety of clinical conditions including cardiovascular injury, kidney failure, cancer, and neurological and bone disorders. Despite the advantages, stem cell therapy is still limited by low survival, engraftment, and homing to damage area as well as inefficiencies in differentiating into fully functional tissues. Genetic engineering of mesenchymal stem cells is being explored as a means to circumvent some of these problems. This review presents the current understanding of the use of genetically engineered mesenchymal stem cells in human disease therapy with emphasis on genetic modifications aimed to improve survival, homing, angiogenesis, and heart function after myocardial infarction. Advancements in other disease areas are also discussed.
dc.format.extent 1513 - 1526
dc.language ENG
dc.language.iso en_US en_US
dc.relation.ispartof Hum Gene Ther
dc.relation.isversionof 10.1089/hum.2010.165
dc.subject Bone Marrow Transplantation
dc.subject Cardiovascular Diseases
dc.subject Cell Differentiation
dc.subject Clinical Trials as Topic
dc.subject Genetic Engineering
dc.subject Humans
dc.subject Mesenchymal Stem Cell Transplantation
dc.subject Mesenchymal Stromal Cells
dc.subject Neoplasms
dc.subject Nervous System Diseases
dc.subject Osteogenesis
dc.subject Renal Insufficiency
dc.title Genetic engineering of mesenchymal stem cells and its application in human disease therapy.
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-11-0 en_US
duke.description.endpage 1526 en_US
duke.description.issue 11 en_US
duke.description.startpage 1513 en_US
duke.description.volume 21 en_US
dc.relation.journal Human Gene Therapy en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20825283
pubs.issue 11
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Faculty
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Cardiology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pathology
pubs.publication-status Published
pubs.volume 21
dc.identifier.eissn 1557-7422

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