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dc.contributor.author Evsyukova, I
dc.contributor.author Somarelli, JA
dc.contributor.author Gregory, SG
dc.contributor.author Garcia-Blanco, MA
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:21:59Z
dc.date.issued 2010-07
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20639696
dc.identifier 12301
dc.identifier.citation RNA Biol, 2010, 7 (4), pp. 462 - 473
dc.identifier.uri http://hdl.handle.net/10161/3963
dc.description.abstract Alternative splicing is a general mechanism for regulating gene expression that affects the RNA products of more than 90% of human genes. Not surprisingly, alternative splicing is observed among gene products of metazoan immune systems, which have evolved to efficiently recognize pathogens and discriminate between "self" and "non-self", and thus need to be both diverse and flexible. In this review we focus on the specific interface between alternative splicing and autoimmune diseases, which result from a malfunctioning of the immune system and are characterized by the inappropriate reaction to self-antigens. Despite the widespread recognition of alternative splicing as one of the major regulators of gene expression, the connections between alternative splicing and autoimmunity have not been apparent. We summarize recent findings connecting splicing and autoimmune disease, and attempt to find common patterns of splicing regulation that may advance our understanding of autoimmune diseases and open new avenues for therapy.
dc.format.extent 462 - 473
dc.language ENG
dc.language.iso en_US en_US
dc.relation.ispartof RNA Biol
dc.subject Alternative Splicing
dc.subject Animals
dc.subject Autoimmune Diseases
dc.subject Exons
dc.subject Humans
dc.subject Multiple Sclerosis
dc.subject Receptors, Interleukin-7
dc.title Alternative splicing in multiple sclerosis and other autoimmune diseases.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-8-jul en_US
duke.description.endpage 473 en_US
duke.description.issue 4 en_US
duke.description.startpage 462 en_US
duke.description.volume 7 en_US
dc.relation.journal Rna Biology en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20639696
pubs.issue 4
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Molecular Genetics and Microbiology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Medical Genetics
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Molecular Physiology Institute
pubs.publication-status Published
pubs.volume 7
dc.identifier.eissn 1555-8584

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