Browsing Duke Dissertations by Duke Department "Biomedical Engineering"

Now showing items 21-40 of 126

Clinical Detection of Dysplasia Using Angle-Resolved Low Coherence Interferometry

Terry, Neil Gordon (2011)

Cancer is now the leading cause of death in developed countries. Despite advances in strategies aimed at the prevention and treatment of the disease, early detection of precancerous growths remains the most effective ...
Computational Modeling of Epidural Cortical Stimulation: Design, Analysis, and Experimental Evaluation

Wongsarnpigoon, Amorn (2011)

Epidural cortical stimulation (ECS) is a developing therapy for many neurological disorders. However, the mechanisms by which ECS has its effects are unknown, and this lack of understanding has limited the development ...
Computational Molecular Engineering Nucleic Acid Binding Proteins and Enzymes

Reza, Faisal (2010)

Interactions between nucleic acid substrates and the proteins and enzymes that bind and catalyze them are ubiquitous and essential for reading, writing, replicating, repairing, and regulating the genomic code by the ...
Computer Aided Detection of Masses in Breast Tomosynthesis Imaging Using Information Theory Principles

Singh, Swatee (2008-09-18)

Breast cancer screening is currently performed by mammography, which is limited by overlying anatomy and dense breast tissue. Computer aided detection (CADe) systems can serve as a double reader to improve radiologist ...
Computer Model of Mechanisms Underlying Dynamic Electrocardiographic T-wave Changes

Doshi, Ashish Nikhil (2011)

Sudden death from arrhythmia is a major cause of mortality in the United States. Unfortunately, no current diagnostic test can accurately predict risk for sudden arrhythmic death. Because ventricular arrhythmias often ...
Control of Bladder Function by Electrical Stimulation of Pudendal Afferents

Woock, John (2010)

Spinal cord injury (SCI) and other neurological diseases and disorders can cause urinary dysfunction that can cause serious health problems and reduce an individual's quality of life. Current methods for treating urinary ...
Correlation Imaging for Improved Cancer Detection

Chawla, Amarpreet (2008-11-10)

We present a new x-ray imaging technique, Correlation Imaging (CI), for improved breast and lung cancer detection. In CI, multiple low-dose radiographic images are acquired along a limited angular arc. Information from ...
Design and Evaluation of a Transcutaneous Energy Transfer System

Bossetti, Chad A (2009)

A clinically viable brain-machine interface (BMI) requires a fully-implanted wireless neural acquisition system to limit the impediments of percutaneous connections. For an implanted system with an appreciable telemetry ...
Development and Design of a Near-Field High-Energy Gamma Camera for Use with Neutron Stimulated Emission Computed Tomography

Sharma, Amy Congdon (2007-12-10)

A new gamma imaging method, Neutron Stimulated Emission Computed Tomography (NSECT), is being developed to non-invasively and non-destructively measure and image elemental concentrations in vivo. In NSECT a beam of fast ...
Development and Optimization of a Dedicated Dual-Modality SPECT-CT System for Improved Breast Lesion Diagnosis

Madhav, Priti (2010)

X-ray mammography is the most widely used breast cancer imaging technique. However, over 400,000 women newly diagnosed each year are misdiagnosed and undergo a biopsy. Current mammography techniques are limited by: (1) ...
Development of a Fourier Domain Low Coherence Interferometry Optical System for Applications in Early Cancer Detection

Graf, Robert Nicholas (2009)

Cancer is a disease that affects millions of people each year. While methods for the prevention and treatment of the disease continue to advance, the early detection of precancerous development remains a key factor in ...
Development of an Integrated SPECT-CmT Dedicated Breast Imaging System Incorporating Novel Data Acquisition and Patient Bed Designs

Crotty, Dominic (2010)

This thesis research builds upon prior work that developed separate SPECT and CT (computed mammotomography, or breast CT) devices that were independently capable of imaging an uncompressed breast in 3D space. To further ...
Development of a Wide Field Diffuse Reflectance Spectral Imaging System for Breast Tumor Margin Assessment

Lo, Justin (2012)

Breast conserving surgery (BCS) is a common treatment option for breast cancer patients. The goal of BCS is to remove the entire tumor from the breast while preserving as much normal tissue as possible for a better ...
Development of Coherence-Gated and Resolution-Multiplexed Optical Imaging Systems

Tao, Yuankai Kenny (2010)

Optical interrogation techniques are particularly well-suited for imaging tissue morphology, biological dynamics, and disease pathogenesis by providing noninvasive access to subcellular-resolution diagnostic information. ...
Development of Depot Forming Elastin-Like Polypeptide-Curcumin Drug Conjugates for Sustained Drug Delivery to Treat Neuroinflammatory Pathologies

Sinclair, Steven Michael (2013)

Neuroinflammation associated with lumbar radiculopathy and peripheral nerve injury is characterized by locally increased levels of the pro-inflammatory cytokine tumor necrosis factor alpha (TNFα). Systemic ...
Development of Extended-Depth Swept Source Optical Coherence Tomography for Applications in Ophthalmic Imaging of the Anterior and Posterior Eye

Dhalla, Al-Hafeez Zahir (2012)

Optical coherence tomography (OCT) is a non-invasive optical imaging modality that provides micron-scale resolution of tissue micro-structure over depth ranges of several millimeters. This imaging technique has had a ...
Development of Fourier Domain Optical Coherence Tomography for Applications in Developmental Biology

Davis, Anjul M. (2008-06-05)

Developmental biology is a field in which explorations are made to answer how an organism transforms from a single cell to a complex system made up of trillions of highly organized and highly specified cells. This field, ...
Development of MR Thermometry Strategies for Hyperthermia of Extremity and Breast Tumors

Wyatt, Cory Robert (2010)

Numerous studies have shown that the combination of radiation therapy and hyperthermia, when delivered at moderate temperatures (40°-45°C) for sustained times (30-90 minutes), can help to provide palliative relief and ...
Development of Plasmonics-active Nanoconstructs for Targeting, Tracking, and Delivery in Single Cells

Gregas, Molly K. (2010)

Although various proof-of-concept studies have demonstrated the eventual potential of a multifunctional SERS-active metallic nanostructures for biological applications such as single cell analysis/measurement and drug ...
Development of Plasmonics-based Optical Nanoprobes for Medical Diagnosis

Wang, Hsinneng (2012)

The development of practical and sensitive techniques for screening early biomarkers such as nucleic acid targets related to medical diseases and cancers is critical for early diagnosis, prevention and effective ...