Browsing Duke Dissertations by Duke Department "Immunology"

Now showing items 1-20 of 27

Analysis of TCR Signaling and Erk Activation in T Cell Development and Autoimmunity

Fuller, Deirdre Marie (2012)

LAT is a transmembrane adaptor protein that is critical for the emanation of signals downstream of the TCR. Following TCR engagement, LAT is phosphorylated on multiple tyrosine residues, allowing it to serve as a ...
B Lymphocyte Effector Functions in Health and Disease

DiLillo, David John (2010)

B cells and humoral immunity make up an important component of the immune system and play a vital role in preventing and fighting off infection by various pathogens. B cells also have been implicated in the pathogenesis ...
Cellular Trafficking and Activation within Lymph Nodes: Contributions to Immunity and Pathogenic or Therapeutic Implications

St. John, Ashley Lauren (2010)

Lymph nodes are organs of efficiency. Once activated, they essentially function to optimize and accelerate the production of the adaptive immune response, which has the potential to determine survival of the host during ...
The Development and Function of Memory Regulatory T Cells

Sanchez, Ana (2010)

Naturally occurring CD4+CD25+Foxp3+ regulatory T cells (TReg) are a cell lineage that develops in the thymus and exits to the periphery, where they represent 5-10% of the peripheral CD4+ T cell population. Phenotypically, ...
Effects of Dysregulated Diacylglycerol-Mediated Signaling on T Cell Function

Krishna, Sruti (2013)

Diacylglycerol (DAG), a lipid messenger generated upon T cell receptor (TCR) engagement, mediates signaling through the IKK/NF-κB and Ras/ERK pathways. Further downstream of the Ras/ERK pathway are mammalian target ...
An Entirely Cell-based System to Generate Single-chain Antibodies against Cell Surface Toll-like Receptors

Chen, Yu-Hsun Jason (2008-12-11)

The generation of recombinant antibodies (Abs) using phage display is a proven method to obtain a large variety of Abs that bind with high affinity to a given antigen (Ag). Traditionally, the generation of single chain ...
The Function of LAT in T Cell Activation and Autoimmunity

Chuck, Mariana (2010)

LAT (linker for activation of T cells) is an important transmembrane adaptor protein in TCR-mediated signaling. Upon TCR engagement, LAT associates with multiple proteins which allows for the activation of downstream ...
The Influence of B-cell Tolerance on Humoral Immunity to HIV-1

Holl, Thomas Matthew (2010)

Several HIV-1 neutralizing antibodies (e.g. 2F5, 4E10) have been shown to react with self-antigens, suggesting that effective humoral responses to HIV-1 may be constrained by the tolerization of HIV-reactive B cells ...
The Innate Immune Response to Vaccinia Viral Infection

Martinez, Jennifer Ashley (2010)

Vaccinia virus (VV) is the most thoroughly studied member of the Poxviridae family and the vaccine used to achieve the only successful eradication of a human disease. Over the years, it has proven itself as a useful ...
Intrinsic Mechanisms that Regulate T Cell Homeostasis and Function

O'Brien, Thomas Francis (2011)

The unique functional attributes possessed by T cells are initiated after stimulation via their T cell receptor (TCR). Due to the T cell's integral role in immune function, the regulation of signaling events downstream ...
Investigation of the initiation and progression of exocrinopathy in Id3-/- mice

Mahlios, Joshua (2012)

Proper regulation of the immune system with regards to development, reaction specificity, and duration is necessary to prevent immune reactions directed against the host that can have a number of potentially lethal ...
Ligand Bias by the Endogenous Agonists of CCR7

Zidar, David Alexander (2009)

Chemokine receptors are members of the seven transmembrane receptor (7TMR) superfamily and are regulated by the G-protein coupled Receptor Kinase (GRK)/ b-arrestin system. CCL19 and CCL21 are endogenous agonists for ...
MyD88 Signaling in B-cell Development and Differentiation

Snowden, Pilar Brooke (2012)

Toll-like receptor (TLR) signaling pathways have been demonstrated to be important in many aspects of innate and adaptive immunity. Binding of TLRs by their respective ligands initiates signaling cascades which promote ...
Regulating Emergency Granulopoiesis

Cain, Derek Wilson (2010)

Normally, neutrophil pools are maintained by "steady-state" granulopoiesis. Infections and inflammation, however, trigger neutrophilias that are supported by a hematopoietic program of accelerated granulopoiesis known ...
Regulation of myeloid cell survival and homeostasis by c-FLIP

Gordy, Claire Lee (2011)

Macrophages play vital roles in pathogen clearance, initiation of immune responses, and maintenance of immune homeostasis; however, current understanding of the contributions of macrophages to these processes <italic>in ...
Regulation of Tcra/Tcrd Locus Conformation during Thymocyte Development

Shih, Han-Yu (2012)

The chromatin architecture of antigen receptor loci has been hypothesized to facilitate the assembly of variable (V), diversity (D), and joining (J) gene segments during lymphocyte development. The 1.6 megabase Tcra/Tcrd ...
The Role of Adaptor Proteins in T Cell Development, Activation, and Homeostasis

Shen, Shudan (2009)

Linker for activation of T cells (LAT) is a transmembrane adaptor protein that lacks any intrinsic enzymatic or transcriptional activity. Upon TCR engagement, LAT is phosphorylated at its membrane-distal tyrosine residues, ...
The Role of CD4+ T cells in the CD8+ T cell Response to Vaccinia Viral Infection

Novy, Patricia Lynne (2010)

The role of CD4 T cell help in primary and secondary CD8 T cell responses to infectious pathogens remains incompletely defined. The primary CD8 T response to infections was initially thought to be largely independent ...
The Role of Epigenetics in Regulating V(D)J Recombination and Allelic Exclusion

Kondilis-Mangum, Hrisavgi Demetrios (2011)

As members of the adaptive immune response, T- and B- cells express unique antigen receptors generated from antigen receptor loci. These loci encode multiple Variable (V), Diversity (D), and Joining (J) gene segments. ...
Role of E-proteins in B Lymphocyte Commitment and Thymocyte Selection

Jones, Mary Elizabeth (2009)

The E-protein transcription factors E2A and HEB regulate various cell processes during the development of B and T lymphocytes, including cell differentiation, lineage commitment, recombination of immune receptor genes, ...