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dc.contributor.author Sauer, Scott en_US
dc.contributor.author Garnsey, Michelle R. en_US
dc.contributor.author Coltart, Dr Don en_US
dc.date.accessioned 2011-06-21T17:26:22Z
dc.date.available 2011-06-21T17:26:22Z
dc.date.issued 2010 en_US
dc.identifier.citation Sauer,Scott J.;Garnsey,Michelle R.;Coltart,Don M.. 2010. Direct Carbon-Carbon Bond Formation via Reductive Soft Enolization: A Kinetically Controlled syn-Aldol Addition of alpha-Halo Thioesters and Enolizable Aldehydes. Journal of the American Chemical Society 132(40): 13997-13999. en_US
dc.identifier.issn 0002-7863 en_US
dc.identifier.uri http://hdl.handle.net/10161/4045
dc.description.abstract The direct addition of enolizable aldehydes and a-halo thioesters to produce beta-hydroxy thioesters enabled by reductive soft enolization is reported. The transformation is operationally simple and efficient and has the unusual feature of giving high syn-selectivity, which is the opposite of that produced for (thio)esters under conventional conditions. Moreover, excellent diastereoselectivity results when a chiral nonracemic alpha-hydroxy aldehyde derivative is used. en_US
dc.language.iso en_US en_US
dc.publisher AMER CHEMICAL SOC en_US
dc.relation.isversionof doi:10.1021/ja1057407 en_US
dc.subject trifluoroethyl thioesters en_US
dc.subject polyketide synthases en_US
dc.subject ketones en_US
dc.subject triethylamine en_US
dc.subject bases en_US
dc.subject chemistry, multidisciplinary en_US
dc.title Direct Carbon-Carbon Bond Formation via Reductive Soft Enolization: A Kinetically Controlled syn-Aldol Addition of alpha-Halo Thioesters and Enolizable Aldehydes en_US
dc.title.alternative en_US
dc.description.version Version of Record en_US
duke.date.pubdate 2010-10-13 en_US
duke.description.endpage 13999 en_US
duke.description.issue 40 en_US
duke.description.startpage 13997 en_US
duke.description.volume 132 en_US
dc.relation.journal Journal of the American Chemical Society en_US

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