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dc.contributor.author Guo, Senli en_US
dc.contributor.author Li, Nan en_US
dc.contributor.author Lad, Nimit en_US
dc.contributor.author Desai, Shivam en_US
dc.contributor.author Akhremitchev, Boris B. en_US
dc.date.accessioned 2011-06-21T17:26:38Z
dc.date.available 2011-06-21T17:26:38Z
dc.date.issued 2010 en_US
dc.identifier.citation Guo,Senli;Li,Nan;Lad,Nimit;Desai,Shivam;Akhremitchev,Boris B.. 2010. Distributions of Parameters and Features of Multiple Bond Ruptures in Force Spectroscopy by Atomic Force Microscopy. Journal of Physical Chemistry C 114(19): 8755-8765. en_US
dc.identifier.issn 1932-7447 en_US
dc.identifier.uri http://hdl.handle.net/10161/4065
dc.description.abstract Force spectroscopy measurement of rupture forces of bound molecules becomes an important physicochemical tool in characterizing intermolecular interactions, Atomic force microscopy (AFM) measurements are among the most common approaches in implementation of this technique. Kinetic information about the molecular bond under study is usually extracted assuming that the detected rupture force comes from rupturing of a single bond. However, multiple bond ruptures might occur in experiments. In this article, we consider how the presence of multiple bonds is manifested in the distribution of parameters that are typically extracted in force spectroscopy experiments. Of particular interest here are the distributions of rupture forces and Kuhn lengths of polymeric tethers. We show that multiple bond ruptures might contribute to the measured distributions even when these distributions have a well-defined single peak. Also, we consider how the probability to form multiple bonds depends on probe velocity. The developed analytical models are applied to experimental data of biotin streptavidin ruptures. The velocity dependence of the amplitude of high force tail supports the hypothesis of multiple bond nature of the measured high forces. en_US
dc.language.iso en_US en_US
dc.publisher AMER CHEMICAL SOC en_US
dc.relation.isversionof doi:10.1021/jp100543u en_US
dc.subject molecular adhesion en_US
dc.subject systematic-errors en_US
dc.subject energy landscapes en_US
dc.subject single en_US
dc.subject kinetics en_US
dc.subject biotin en_US
dc.subject afm en_US
dc.subject strength en_US
dc.subject dissociation en_US
dc.subject mechanics en_US
dc.subject chemistry, physical en_US
dc.subject nanoscience & nanotechnology en_US
dc.subject materials science, multidisciplinary en_US
dc.title Distributions of Parameters and Features of Multiple Bond Ruptures in Force Spectroscopy by Atomic Force Microscopy en_US
dc.title.alternative en_US
dc.description.version Version of Record en_US
duke.date.pubdate 2010-5-20 en_US
duke.description.endpage 8765 en_US
duke.description.issue 19 en_US
duke.description.startpage 8755 en_US
duke.description.volume 114 en_US
dc.relation.journal Journal of Physical Chemistry C en_US

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