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dc.contributor.author Peles, Dana N. en_US
dc.contributor.author Lin, Erica en_US
dc.contributor.author Simon, John D. en_US
dc.date.accessioned 2011-06-21T17:26:44Z
dc.date.available 2011-06-21T17:26:44Z
dc.date.issued 2010 en_US
dc.identifier.citation Peles,Dana N.;Lin,Erica;Wakamatsu,Kazumasa;Ito,Shosuke;Simon,John D.. 2010. Ultraviolet Absorption Coefficients of Melanosomes Containing Eumelanin As Related to the Relative Content of DHI and DHICA. Journal of Physical Chemistry Letters 1(15): 2391-2395. en_US
dc.identifier.issn 1948-7185 en_US
dc.identifier.uri http://hdl.handle.net/10161/4080
dc.description.abstract Central to understanding the photochemical function(s) of melanosomes is the determination of their absorption properties and an understanding of how the absorption varies with the molecular composition of melanin. Herein, the absorption coefficients for melanosomes containing predominantly eumelanin, a polymeric pigment derived from the molecular precursors 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole-2-carboxylic acid (DHICA), are reported for) lambda = 244 nm. The absorption coefficient varies with the DHICA/DHI ratio, determined from chemical degradation analyses. With increasing DHICA content, the absorption coefficient of the melanosome increases. This observation is consistent with reported extinction coefficients, which reveal that at 244 nm, the extinction coefficient of DHICA is a factor of similar to 2.1 greater than that of DHI. The melanosome absorption coefficients are compared to predicted values based on a linear combination of the absorption of the constituent monomers. en_US
dc.language.iso en_US en_US
dc.publisher AMER CHEMICAL SOC en_US
dc.relation.isversionof doi:10.1021/jz100720h en_US
dc.subject retinal-pigment epithelium en_US
dc.subject 5,6-dihydroxyindole-2-carboxylic acid en_US
dc.subject dopachrome tautomerase en_US
dc.subject chemical-properties en_US
dc.subject melanin en_US
dc.subject oligomers en_US
dc.subject threshold en_US
dc.subject skin en_US
dc.subject chemistry, physical en_US
dc.subject nanoscience & nanotechnology en_US
dc.subject materials science, multidisciplinary en_US
dc.subject physics, atomic, molecular & chemical en_US
dc.title Ultraviolet Absorption Coefficients of Melanosomes Containing Eumelanin As Related to the Relative Content of DHI and DHICA en_US
dc.title.alternative en_US
dc.description.version Version of Record en_US
duke.date.pubdate 2010-8-5 en_US
duke.description.endpage 2395 en_US
duke.description.issue 15 en_US
duke.description.startpage 2391 en_US
duke.description.volume 1 en_US
dc.relation.journal Journal of Physical Chemistry Letters en_US

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