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dc.contributor.author Akhremitchev, Boris B. en_US
dc.date.accessioned 2011-06-21T17:26:44Z
dc.date.available 2011-06-21T17:26:44Z
dc.date.issued 2010 en_US
dc.identifier.citation Averett,Laurel E.;Akhremitchev,Boris B.;Schoenfisch,Mark H.;Gorkun,Oleg V.. 2010. Calcium Dependence of Fibrin Nanomechanics: The gamma 1 Calcium Mediates the Unfolding of Fibrinogen Induced by Force Applied to the "A-a" Bond. Langmuir 26(18): 14716-14722. en_US
dc.identifier.issn 0743-7463 en_US
dc.identifier.uri http://hdl.handle.net/10161/4081
dc.description.abstract The interactions between the constituent monomers of fibrin, the polymerized protein network that provides the structural stability of blood clots, ale frequently under stress because of the dynamic nature of blood flow Herein, the calcium dependence of the structural unfolding linked to the forced dissociation of the "A-a" knob-hole bond between fibrin monomers is reported The presence of calcium was shown to influence the incidence of the last event in the unfolding pattern characteristic of "A-a" rupture This effect, attributed to the function of the gamma 1 calcium-binding site, was found to be reversible and specific Our results indicate that binding of calcium at the gamma 1 site has no effect on the strength of the knob-hole bond prior to unfolding of the hole-containing gamma module Rather, calcium bound at the gamma 1 site makes the structure of the hole mole resilient to such forced unfolding, leading to survival of the "A-a" knob-hole bond during large: extensions of the fibrinogen molecule but at the cost of rupture of the bond at lower forces en_US
dc.language.iso en_US en_US
dc.publisher AMER CHEMICAL SOC en_US
dc.relation.isversionof doi:10.1021/la.1017664 en_US
dc.subject b-b interactions en_US
dc.subject crystal-structure en_US
dc.subject single-molecule en_US
dc.subject vlissingen/frankfurt iv en_US
dc.subject platelet-aggregation en_US
dc.subject polymerization site en_US
dc.subject n-terminus en_US
dc.subject binding en_US
dc.subject chain en_US
dc.subject fragment en_US
dc.subject chemistry, multidisciplinary en_US
dc.subject chemistry, physical en_US
dc.subject materials science, multidisciplinary en_US
dc.title Calcium Dependence of Fibrin Nanomechanics: The gamma 1 Calcium Mediates the Unfolding of Fibrinogen Induced by Force Applied to the "A-a" Bond en_US
dc.title.alternative en_US
dc.description.version Version of Record en_US
duke.date.pubdate 2010-9-21 en_US
duke.description.endpage 14722 en_US
duke.description.issue 18 en_US
duke.description.startpage 14716 en_US
duke.description.volume 26 en_US
dc.relation.journal Langmuir en_US

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