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dc.contributor.author Perez, LR
dc.contributor.author Franz, KJ
dc.coverage.spatial England
dc.date.accessioned 2011-06-21T17:27:13Z
dc.date.issued 2010-03-07
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20162187
dc.identifier.citation Dalton Trans, 2010, 39 (9), pp. 2177 - 2187
dc.identifier.uri http://hdl.handle.net/10161/4119
dc.description.abstract Neurodegenerative diseases like Alzheimer's and Parkinson's disease are associated with elevated levels of iron, copper, and zinc and consequentially high levels of oxidative stress. Given the multifactorial nature of these diseases, it is becoming evident that the next generation of therapies must have multiple functions to combat multiple mechanisms of disease progression. Metal-chelating agents provide one such function as an intervention for ameliorating metal-associated damage in degenerative diseases. Targeting chelators to adjust localized metal imbalances in the brain, however, presents significant challenges. In this perspective, we focus on some noteworthy advances in the area of multifunctional metal chelators as potential therapeutic agents for neurodegenerative diseases. In addition to metal chelating ability, these agents also contain features designed to improve their uptake across the blood-brain barrier, increase their selectivity for metals in damage-prone environments, increase antioxidant capabilities, lower Abeta peptide aggregation, or inhibit disease-associated enzymes such as monoamine oxidase and acetylcholinesterase.
dc.format.extent 2177 - 2187
dc.language ENG
dc.language.iso en_US en_US
dc.relation.ispartof Dalton Trans
dc.relation.isversionof 10.1039/b919237a
dc.subject Chelating Agents
dc.subject Humans
dc.subject Metals
dc.subject Neurodegenerative Diseases
dc.title Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-00-00 en_US
duke.description.endpage 2187 en_US
duke.description.issue 9 en_US
duke.description.startpage 2177 en_US
duke.description.volume 39 en_US
dc.relation.journal Dalton Transactions en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20162187
pubs.issue 9
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.organisational-group /Duke/Trinity College of Arts & Sciences
pubs.organisational-group /Duke/Trinity College of Arts & Sciences/Chemistry
pubs.publication-status Published
pubs.volume 39
dc.identifier.eissn 1477-9234

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