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dc.contributor.author Ho, YP
dc.contributor.author Leong, KW
dc.date.accessioned 2011-06-21T17:27:14Z
dc.date.issued 2010
dc.identifier.citation Nanoscale, 2010, 2 (1), pp. 60 - 68
dc.identifier.uri http://hdl.handle.net/10161/4124
dc.description.abstract Luminescent semiconductor nanocrystals, also known as quantum dots (QDs), have advanced the fields of molecular diagnostics and nanotherapeutics. Much of the initial progress for QDs in biology and medicine has focused on developing new biosensing formats to push the limit of detection sensitivity. Nevertheless. QDs can be more than passive bio-probes or labels for biological imaging and cellular studies. The high surface-to-volume ratio of QDs enables the construction of a "smart" multifunctional nanoplatform, where the QDs serve not only as an imaging agent but also a nanoscaffold catering for therapeutic and diagnostic (theranostic) modalities. This mini review highlights the emerging applications of functionalized QDs as fluorescence contrast agents for imaging or as nanoscale vehicles for delivery of therapeutics, with special attention paid to the promise and challenges towards QD-based theranostics.
dc.format.extent 60 - 68
dc.language.iso en_US en_US
dc.relation.ispartof Nanoscale
dc.subject resonance energy-transfer in-vivo semiconductor nanocrystals gene delivery multifunctional nanoparticles intracellular delivery gold nanoparticles cellular uptake sirna delivery cancer-therapy
dc.title Quantum dot-based theranostics
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-1-0 en_US
duke.description.endpage 68 en_US
duke.description.issue 1 en_US
duke.description.startpage 60 en_US
duke.description.volume 2 en_US
dc.relation.journal Nanoscale en_US
pubs.issue 1
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Pratt School of Engineering
pubs.organisational-group /Duke/Pratt School of Engineering/Biomedical Engineering
pubs.organisational-group /Duke/Pratt School of Engineering/Mechanical Engineering and Materials Science
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Surgery
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Surgery/Surgery, Surgical Sciences
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.publication-status Published
pubs.volume 2

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