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dc.contributor.author Harrell, Lizzie J. en_US
dc.date.accessioned 2011-06-21T17:27:18Z
dc.date.available 2011-06-21T17:27:18Z
dc.date.issued 2010 en_US
dc.identifier.citation Snydman,David R.;Jacobus,Nilda V.;McDermott,Laura A.;Golan,Yoav;Hecht,David W.;Goldstein,Ellie J. C.;Harrell,Lizzie;Jenkins,Stephen;Newton,Duane;Pierson,Carl;Rihs,John D.;Yu,Victor L.;Venezia,Richard;Finegold,Sydney M.;Rosenblatt,Jon E.;Gorbach,Sherwood L.. 2010. Lessons Learned from the Anaerobe Survey: Historical Perspective and Review of the Most Recent Data (2005-2007). Clinical Infectious Diseases 50( ): S26-S33. en_US
dc.identifier.issn 1058-4838 en_US
dc.identifier.uri http://hdl.handle.net/10161/4135
dc.description.abstract Background. The rationale and lessons learned through the evolution of the National Survey for the Susceptibility of Bacteroides fragilis Group from its initiation in 1981 through 2007 are reviewed here. The survey was conceived in 1980 to track emerging antimicrobial resistance in Bacteroides species. Methods. Data from the last 11 years of the survey (1997-2007), including 6574 isolates from 13 medical centers, were analyzed for in vitro antimicrobial resistance to both frequently used and newly developed anti-anaerobic agents. The minimum inhibitory concentrations of the antibiotics were determined using agar dilution in accordance with Clinical and Laboratory Standards Institute recommendations. Results. The analyses revealed that the carbapenems (imipenem, meropenem, ertapenem, and doripenem) and piperacillin-tazobactam were the most active agents against these pathogens, with resistance rates of 0.9%-2.3%. In the most recent 3 years of the survey (2005-2007), resistance to some agents was shown to depend on the species, such as ampicillin-sulbactam against Bacteroides distasonis (20.6%) and tigecycline against Bacteroides uniformis and Bacteroides eggerthii (similar to 7%). Very high resistance rates (>50%) were noted for moxifloxacin and trovafloxacin, particularly against Bacteroides vulgatus. During that period of study, non-B. fragilis Bacteroides species had >40% resistance to clindamycin. Metronidazole-resistant Bacteroides strains were also first reported during that period. Conclusions. In summary, resistance to antibiotics was greater among non-B. fragilis Bacteroides species than among B. fragilis and was especially greater among species with a low frequency of isolation, such as Bacteroides caccae and B. uniformis. The emergence of resistance among the non-B. fragilis Bacteroides species underscores the need for speciation of B. fragilis group isolates and for clinicians to be aware of associations between species and drug resistance. en_US
dc.language.iso en_US en_US
dc.publisher UNIV CHICAGO PRESS en_US
dc.relation.isversionof doi:10.1086/647940 en_US
dc.subject bacteroides-fragilis group en_US
dc.subject antimicrobial susceptibility patterns en_US
dc.subject in-vitro activities en_US
dc.subject united-states en_US
dc.subject national-survey en_US
dc.subject resistance en_US
dc.subject trends en_US
dc.subject multicenter en_US
dc.subject bacteria en_US
dc.subject immunology en_US
dc.subject infectious diseases en_US
dc.subject microbiology en_US
dc.title Lessons Learned from the Anaerobe Survey: Historical Perspective and Review of the Most Recent Data (2005-2007) en_US
dc.title.alternative en_US
dc.description.version Version of Record en_US
duke.date.pubdate 2010-1-1 en_US
duke.description.endpage S33 en_US
duke.description.issue en_US
duke.description.startpage S26 en_US
duke.description.volume 50 en_US
dc.relation.journal Clinical Infectious Diseases en_US

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