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dc.contributor.author Perfect, JR
dc.contributor.author Dismukes, WE
dc.contributor.author Dromer, F
dc.contributor.author Goldman, DL
dc.contributor.author Graybill, JR
dc.contributor.author Hamill, RJ
dc.contributor.author Harrison, TS
dc.contributor.author Larsen, RA
dc.contributor.author Lortholary, O
dc.contributor.author Nguyen, MH
dc.contributor.author Pappas, PG
dc.contributor.author Powderly, WG
dc.contributor.author Singh, N
dc.contributor.author Sobel, JD
dc.contributor.author Sorrell, TC
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:27:18Z
dc.date.issued 2010-02-01
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20047480
dc.identifier.citation Clin Infect Dis, 2010, 50 (3), pp. 291 - 322
dc.identifier.uri http://hdl.handle.net/10161/4137
dc.description.abstract Cryptococcosis is a global invasive mycosis associated with significant morbidity and mortality. These guidelines for its management have been built on the previous Infectious Diseases Society of America guidelines from 2000 and include new sections. There is a discussion of the management of cryptococcal meningoencephalitis in 3 risk groups: (1) human immunodeficiency virus (HIV)-infected individuals, (2) organ transplant recipients, and (3) non-HIV-infected and nontransplant hosts. There are specific recommendations for other unique risk populations, such as children, pregnant women, persons in resource-limited environments, and those with Cryptococcus gattii infection. Recommendations for management also include other sites of infection, including strategies for pulmonary cryptococcosis. Emphasis has been placed on potential complications in management of cryptococcal infection, including increased intracranial pressure, immune reconstitution inflammatory syndrome (IRIS), drug resistance, and cryptococcomas. Three key management principles have been articulated: (1) induction therapy for meningoencephalitis using fungicidal regimens, such as a polyene and flucytosine, followed by suppressive regimens using fluconazole; (2) importance of early recognition and treatment of increased intracranial pressure and/or IRIS; and (3) the use of lipid formulations of amphotericin B regimens in patients with renal impairment. Cryptococcosis remains a challenging management issue, with little new drug development or recent definitive studies. However, if the diagnosis is made early, if clinicians adhere to the basic principles of these guidelines, and if the underlying disease is controlled, then cryptococcosis can be managed successfully in the vast majority of patients.
dc.format.extent 291 - 322
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof Clin Infect Dis
dc.relation.isversionof 10.1086/649858
dc.subject Antifungal Agents
dc.subject Case Management
dc.subject Child
dc.subject Child, Preschool
dc.subject Cryptococcosis
dc.subject Female
dc.subject Humans
dc.subject Intracranial Hypertension
dc.subject Pregnancy
dc.subject United States
dc.title Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-2-1 en_US
duke.description.endpage 322 en_US
duke.description.issue 3 en_US
duke.description.startpage 291 en_US
duke.description.volume 50 en_US
dc.relation.journal Clinical Infectious Diseases en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20047480
pubs.issue 3
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Molecular Genetics and Microbiology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Infectious Diseases
pubs.publication-status Published
pubs.volume 50
dc.identifier.eissn 1537-6591

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