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dc.contributor.author Pappas, PG
dc.contributor.author Alexander, BD
dc.contributor.author Andes, DR
dc.contributor.author Hadley, S
dc.contributor.author Kauffman, CA
dc.contributor.author Freifeld, A
dc.contributor.author Anaissie, EJ
dc.contributor.author Brumble, LM
dc.contributor.author Herwaldt, L
dc.contributor.author Ito, J
dc.contributor.author Kontoyiannis, DP
dc.contributor.author Lyon, GM
dc.contributor.author Marr, KA
dc.contributor.author Morrison, VA
dc.contributor.author Park, BJ
dc.contributor.author Patterson, TF
dc.contributor.author Perl, TM
dc.contributor.author Oster, RA
dc.contributor.author Schuster, MG
dc.contributor.author Walker, R
dc.contributor.author Walsh, TJ
dc.contributor.author Wannemuehler, KA
dc.contributor.author Chiller, TM
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:27:19Z
dc.date.issued 2010-04-15
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20218876
dc.identifier.citation Clin Infect Dis, 2010, 50 (8), pp. 1101 - 1111
dc.identifier.uri http://hdl.handle.net/10161/4144
dc.description.abstract BACKGROUND: Invasive fungal infections (IFIs) are a major cause of morbidity and mortality among organ transplant recipients. Multicenter prospective surveillance data to determine disease burden and secular trends are lacking. METHODS: The Transplant-Associated Infection Surveillance Network (TRANSNET) is a consortium of 23 US transplant centers, including 15 that contributed to the organ transplant recipient dataset. We prospectively identified IFIs among organ transplant recipients from March, 2001 through March, 2006 at these sites. To explore trends, we calculated the 12-month cumulative incidence among 9 sequential cohorts. RESULTS: During the surveillance period, 1208 IFIs were identified among 1063 organ transplant recipients. The most common IFIs were invasive candidiasis (53%), invasive aspergillosis (19%), cryptococcosis (8%), non-Aspergillus molds (8%), endemic fungi (5%), and zygomycosis (2%). Median time to onset of candidiasis, aspergillosis, and cryptococcosis was 103, 184, and 575 days, respectively. Among a cohort of 16,808 patients who underwent transplantation between March 2001 and September 2005 and were followed through March 2006, a total of 729 IFIs were reported among 633 persons. One-year cumulative incidences of the first IFI were 11.6%, 8.6%, 4.7%, 4.0%, 3.4%, and 1.3% for small bowel, lung, liver, heart, pancreas, and kidney transplant recipients, respectively. One-year incidence was highest for invasive candidiasis (1.95%) and aspergillosis (0.65%). Trend analysis showed a slight increase in cumulative incidence from 2002 to 2005. CONCLUSIONS: We detected a slight increase in IFIs during the surveillance period. These data provide important insights into the timing and incidence of IFIs among organ transplant recipients, which can help to focus effective prevention and treatment strategies.
dc.format.extent 1101 - 1111
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof Clin Infect Dis
dc.relation.isversionof 10.1086/651262
dc.subject Adolescent
dc.subject Adult
dc.subject Aged
dc.subject Aged, 80 and over
dc.subject Child
dc.subject Child, Preschool
dc.subject Cohort Studies
dc.subject Female
dc.subject Humans
dc.subject Immunocompromised Host
dc.subject Incidence
dc.subject Infant
dc.subject Male
dc.subject Middle Aged
dc.subject Mycoses
dc.subject Prospective Studies
dc.subject Sentinel Surveillance
dc.subject Transplants
dc.subject United States
dc.subject Young Adult
dc.title Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET).
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-4-15 en_US
duke.description.endpage 1111 en_US
duke.description.issue 8 en_US
duke.description.startpage 1101 en_US
duke.description.volume 50 en_US
dc.relation.journal Clinical Infectious Diseases en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20218876
pubs.issue 8
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Infectious Diseases
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pathology
pubs.publication-status Published
pubs.volume 50
dc.identifier.eissn 1537-6591

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