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dc.contributor.author Kontoyiannis, DP
dc.contributor.author Marr, KA
dc.contributor.author Park, BJ
dc.contributor.author Alexander, BD
dc.contributor.author Anaissie, EJ
dc.contributor.author Walsh, TJ
dc.contributor.author Ito, J
dc.contributor.author Andes, DR
dc.contributor.author Baddley, JW
dc.contributor.author Brown, JM
dc.contributor.author Brumble, LM
dc.contributor.author Freifeld, AG
dc.contributor.author Hadley, S
dc.contributor.author Herwaldt, LA
dc.contributor.author Kauffman, CA
dc.contributor.author Knapp, K
dc.contributor.author Lyon, GM
dc.contributor.author Morrison, VA
dc.contributor.author Papanicolaou, G
dc.contributor.author Patterson, TF
dc.contributor.author Perl, TM
dc.contributor.author Schuster, MG
dc.contributor.author Walker, R
dc.contributor.author Wannemuehler, KA
dc.contributor.author Wingard, JR
dc.contributor.author Chiller, TM
dc.contributor.author Pappas, PG
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:27:21Z
dc.date.issued 2010-04-15
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20218877
dc.identifier.citation Clin Infect Dis, 2010, 50 (8), pp. 1091 - 1100
dc.identifier.uri http://hdl.handle.net/10161/4145
dc.description.abstract BACKGROUND: The incidence and epidemiology of invasive fungal infections (IFIs), a leading cause of death among hematopoeitic stem cell transplant (HSCT) recipients, are derived mainly from single-institution retrospective studies. METHODS: The Transplant Associated Infections Surveillance Network, a network of 23 US transplant centers, prospectively enrolled HSCT recipients with proven and probable IFIs occurring between March 2001 and March 2006. We collected denominator data on all HSCTs preformed at each site and clinical, diagnostic, and outcome information for each IFI case. To estimate trends in IFI, we calculated the 12-month cumulative incidence among 9 sequential subcohorts. RESULTS: We identified 983 IFIs among 875 HSCT recipients. The median age of the patients was 49 years; 60% were male. Invasive aspergillosis (43%), invasive candidiasis (28%), and zygomycosis (8%) were the most common IFIs. Fifty-nine percent and 61% of IFIs were recognized within 60 days of neutropenia and graft-versus-host disease, respectively. Median onset of candidiasis and aspergillosis after HSCT was 61 days and 99 days, respectively. Within a cohort of 16,200 HSCT recipients who received their first transplants between March 2001 and September 2005 and were followed up through March 2006, we identified 718 IFIs in 639 persons. Twelve-month cumulative incidences, based on the first IFI, were 7.7 cases per 100 transplants for matched unrelated allogeneic, 8.1 cases per 100 transplants for mismatched-related allogeneic, 5.8 cases per 100 transplants for matched-related allogeneic, and 1.2 cases per 100 transplants for autologous HSCT. CONCLUSIONS: In this national prospective surveillance study of IFIs in HSCT recipients, the cumulative incidence was highest for aspergillosis, followed by candidiasis. Understanding the epidemiologic trends and burden of IFIs may lead to improved management strategies and study design.
dc.format.extent 1091 - 1100
dc.language ENG
dc.language.iso en_US en_US
dc.relation.ispartof Clin Infect Dis
dc.relation.isversionof 10.1086/651263
dc.subject Adolescent
dc.subject Adult
dc.subject Aged
dc.subject Child
dc.subject Child, Preschool
dc.subject Cohort Studies
dc.subject Female
dc.subject Hematopoietic Stem Cell Transplantation
dc.subject Humans
dc.subject Immunocompromised Host
dc.subject Incidence
dc.subject Infant
dc.subject Infection Control
dc.subject Male
dc.subject Middle Aged
dc.subject Mycoses
dc.subject Prospective Studies
dc.subject Sentinel Surveillance
dc.subject United States
dc.subject Young Adult
dc.title Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001-2006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-4-15 en_US
duke.description.endpage 1100 en_US
duke.description.issue 8 en_US
duke.description.startpage 1091 en_US
duke.description.volume 50 en_US
dc.relation.journal Clinical Infectious Diseases en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20218877
pubs.issue 8
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Infectious Diseases
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pathology
pubs.publication-status Published
pubs.volume 50
dc.identifier.eissn 1537-6591

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