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dc.contributor.author Alter, G
dc.contributor.author Moody, MA
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:27:22Z
dc.date.issued 2010-10-15
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20846039
dc.identifier.citation J Infect Dis, 2010, 202 Suppl 2 pp. S315 - S322
dc.identifier.uri http://hdl.handle.net/10161/4156
dc.description.abstract During the past 2 decades, significant advances in our understanding of the humoral immune response to human immunodeficiency virus type 1 (HIV-1) infection have been made, yet a tremendous amount of work lies ahead. Despite these advances, strategies to reliably induce antibodies that can control HIV-1 infection are still critically needed. However, recent advances in our understanding of the kinetics, specificity, and function of early humoral responses offer alternative new approaches to attain this goal. These results, along with the new broadly neutralizing antibody specificities, the role for other antibody functions, the increased understanding of HIV-1-induced changes to B cell biology, and results from the RV144 "Thai" trial showing potential modest sterilizing protection by nonneutralizing antibody responses, have renewed focus on the humoral system. In this review, recent advances in our understanding of the earliest humoral responses are discussed, highlighting presentations from the meeting on the Biology of Acute HIV Infection.
dc.format.extent S315 - S322
dc.language ENG
dc.language.iso en_US en_US
dc.relation.ispartof J Infect Dis
dc.relation.isversionof 10.1086/655654
dc.subject Antibodies, Neutralizing
dc.subject HIV Antibodies
dc.subject HIV Infections
dc.subject HIV-1
dc.subject Humans
dc.title The humoral response to HIV-1: new insights, renewed focus.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-10-15 en_US
duke.description.endpage S322 en_US
duke.description.issue en_US
duke.description.startpage S315 en_US
duke.description.volume 202 en_US
dc.relation.journal Journal of Infectious Diseases en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20846039
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Immunology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pediatrics
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pediatrics/Pediatrics, Infectious Diseases
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Human Vaccine Institute
pubs.publication-status Published
pubs.volume 202 Suppl 2
dc.identifier.eissn 1537-6613

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