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dc.contributor.author Dreja, H
dc.contributor.author O'Sullivan, E
dc.contributor.author Pade, C
dc.contributor.author Greene, KM
dc.contributor.author Gao, H
dc.contributor.author Aubin, K
dc.contributor.author Hand, J
dc.contributor.author Isaksen, A
dc.contributor.author D'Souza, C
dc.contributor.author Leber, W
dc.contributor.author Montefiori, D
dc.contributor.author Seaman, MS
dc.contributor.author Anderson, J
dc.contributor.author Orkin, C
dc.contributor.author McKnight, A
dc.coverage.spatial England
dc.date.accessioned 2011-06-21T17:27:29Z
dc.date.issued 2010-11
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20685933
dc.identifier vir.0.024224-0
dc.identifier.citation J Gen Virol, 2010, 91 (Pt 11), pp. 2794 - 2803
dc.identifier.uri http://hdl.handle.net/10161/4167
dc.description.abstract The array of human immunodeficiency virus (HIV) subtypes encountered in East London, an area long associated with migration, is unusually heterogeneous, reflecting the diverse geographical origins of the population. In this study it was shown that viral subtypes or clades infecting a sample of HIV type 1 (HIV-1)-positive individuals in East London reflect the global pandemic. The authors studied the humoral response in 210 treatment-naïve chronically HIV-1-infected (>1 year) adult subjects against a panel of 12 viruses from six different clades. Plasmas from individuals infected with clade C, but also plasmas from clade A, and to a lesser degree clade CRF02_AG and CRF01_AE, were significantly more potent at neutralizing the tested viruses compared with plasmas from individuals infected with clade B. The difference in humoral robustness between clade C- and B-infected patients was confirmed in titration studies with an extended panel of clade B and C viruses. These results support the approach to develop an HIV-1 vaccine that includes clade C or A envelope protein (Env) immunogens for the induction of a potent neutralizing humoral response.
dc.format.extent 2794 - 2803
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof J Gen Virol
dc.relation.isversionof 10.1099/vir.0.024224-0
dc.subject Antibodies, Neutralizing
dc.subject Cohort Studies
dc.subject Female
dc.subject Genotype
dc.subject HIV Antibodies
dc.subject HIV Protease
dc.subject HIV Reverse Transcriptase
dc.subject HIV-1
dc.subject Humans
dc.subject London
dc.subject Male
dc.subject Neutralization Tests
dc.subject Sequence Analysis, DNA
dc.title Neutralization activity in a geographically diverse East London cohort of human immunodeficiency virus type 1-infected patients: clade C infection results in a stronger and broader humoral immune response than clade B infection.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-11-0 en_US
duke.description.endpage 2803 en_US
duke.description.issue en_US
duke.description.startpage 2794 en_US
duke.description.volume 91 en_US
dc.relation.journal Journal of General Virology en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20685933
pubs.issue Pt 11
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Human Vaccine Institute
pubs.volume 91
dc.identifier.eissn 1465-2099

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