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dc.contributor.author Wong, CC
dc.contributor.author Caspi, A
dc.contributor.author Williams, B
dc.contributor.author Craig, IW
dc.contributor.author Houts, R
dc.contributor.author Ambler, A
dc.contributor.author Moffitt, TE
dc.contributor.author Mill, J
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:27:37Z
dc.date.issued 2010-08-16
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20505345
dc.identifier 12226
dc.identifier.citation Epigenetics, 2010, 5 (6), pp. 516 - 526
dc.identifier.uri http://hdl.handle.net/10161/4197
dc.description.abstract DNA methylation is a key epigenetic mechanism involved in the developmental regulation of gene expression. Alterations in DNA methylation are established contributors to inter-individual phenotypic variation and have been associated with disease susceptibility. The degree to which changes in loci-specific DNA methylation are under the influence of heritable and environmental factors is largely unknown. In this study, we quantitatively measured DNA methylation across the promoter regions of the dopamine receptor 4 gene (DRD4), the serotonin transporter gene (SLC6A4/SERT) and the X-linked monoamine oxidase A gene (MAOA) using DNA sampled at both ages 5 and 10 years in 46 MZ twin-pairs and 45 DZ twin-pairs (total n=182). Our data suggest that DNA methylation differences are apparent already in early childhood, even between genetically identical individuals, and that individual differences in methylation are not stable over time. Our longitudinal-developmental study suggests that environmental influences are important factors accounting for interindividual DNA methylation differences, and that these influences differ across the genome. The observation of dynamic changes in DNA methylation over time highlights the importance of longitudinal research designs for epigenetic research.
dc.format.extent 516 - 526
dc.language ENG
dc.language.iso en_US en_US
dc.relation.ispartof Epigenetics
dc.subject Child
dc.subject Child, Preschool
dc.subject DNA Methylation
dc.subject Epigenesis, Genetic
dc.subject Female
dc.subject Genetic Variation
dc.subject Genomic Instability
dc.subject Humans
dc.subject Inheritance Patterns
dc.subject Longitudinal Studies
dc.subject Male
dc.subject Monoamine Oxidase
dc.subject Receptors, Dopamine D4
dc.subject Serotonin Plasma Membrane Transport Proteins
dc.subject Twins
dc.title A longitudinal study of epigenetic variation in twins.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-8-16 en_US
duke.description.endpage en_US
duke.description.issue 6 en_US
duke.description.startpage en_US
duke.description.volume 5 en_US
dc.relation.journal Epigenetics en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20505345
pubs.issue 6
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Duke Institute for Brain Sciences
pubs.organisational-group /Duke/Sanford School of Public Policy
pubs.organisational-group /Duke/Sanford School of Public Policy/Center for Child and Family Policy
pubs.organisational-group /Duke/Sanford School of Public Policy/Duke Population Research Institute
pubs.organisational-group /Duke/Sanford School of Public Policy/Duke Population Research Institute/Center for Population Health & Aging
pubs.organisational-group /Duke/Sanford School of Public Policy/Duke Population Research Institute/Duke Population Research Center
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Psychiatry & Behavioral Sciences
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Psychiatry & Behavioral Sciences/Psychiatry, Child & Family Mental Health and Developmental Neuroscience
pubs.organisational-group /Duke/Trinity College of Arts & Sciences
pubs.organisational-group /Duke/Trinity College of Arts & Sciences/Psychology and Neuroscience
pubs.publication-status Published
pubs.volume 5
dc.identifier.eissn 1559-2308

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