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dc.contributor.author Bydlon, TM
dc.contributor.author Kennedy, SA
dc.contributor.author Richards, LM
dc.contributor.author Brown, JQ
dc.contributor.author Yu, B
dc.contributor.author Junker, MK
dc.contributor.author Gallagher, J
dc.contributor.author Geradts, J
dc.contributor.author Wilke, LG
dc.contributor.author Ramanujam, N
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:27:43Z
dc.date.issued 2010-04-12
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20588651
dc.identifier 197019
dc.identifier.citation Opt Express, 2010, 18 (8), pp. 8058 - 8076
dc.identifier.uri http://hdl.handle.net/10161/4237
dc.description.abstract As many as 20-70% of patients undergoing breast conserving surgery require repeat surgeries due to a close or positive surgical margin diagnosed post-operatively [1]. Currently there are no widely accepted tools for intra-operative margin assessment which is a significant unmet clinical need. Our group has developed a first-generation optical visible spectral imaging platform to image the molecular composition of breast tumor margins and has tested it clinically in 48 patients in a previously published study [2]. The goal of this paper is to report on the performance metrics of the system and compare it to clinical criteria for intra-operative tumor margin assessment. The system was found to have an average signal to noise ratio (SNR) >100 and <15% error in the extraction of optical properties indicating that there is sufficient SNR to leverage the differences in optical properties between negative and close/positive margins. The probe had a sensing depth of 0.5-2.2 mm over the wavelength range of 450-600 nm which is consistent with the pathologic criterion for clear margins of 0-2 mm. There was <1% cross-talk between adjacent channels of the multi-channel probe which shows that multiple sites can be measured simultaneously with negligible cross-talk between adjacent sites. Lastly, the system and measurement procedure were found to be reproducible when evaluated with repeated measures, with a low coefficient of variation (<0.11). The only aspect of the system not optimized for intra-operative use was the imaging time. The manuscript includes a discussion of how the speed of the system can be improved to work within the time constraints of an intra-operative setting.
dc.format.extent 8058 - 8076
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof Opt Express
dc.subject Breast Neoplasms
dc.subject Computer Simulation
dc.subject Diagnostic Imaging
dc.subject Female
dc.subject Humans
dc.subject Intraoperative Care
dc.subject Monte Carlo Method
dc.subject Optical Devices
dc.subject Phantoms, Imaging
dc.subject Reproducibility of Results
dc.subject Spectrum Analysis
dc.title Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-4-12 en_US
duke.description.endpage 8076 en_US
duke.description.issue 8 en_US
duke.description.startpage 8058 en_US
duke.description.volume 18 en_US
dc.relation.journal Optics Express en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20588651
pubs.issue 8
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/Initiatives
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/Initiatives/Duke Science & Society
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Global Health Institute
pubs.organisational-group /Duke/Pratt School of Engineering
pubs.organisational-group /Duke/Pratt School of Engineering/Biomedical Engineering
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Pharmacology & Cancer Biology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pathology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.publication-status Published
pubs.volume 18
dc.identifier.eissn 1094-4087

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