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dc.contributor.author Fu, HL
dc.contributor.author Yu, B
dc.contributor.author Lo, JY
dc.contributor.author Palmer, GM
dc.contributor.author Kuech, TF
dc.contributor.author Ramanujam, N
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:27:43Z
dc.date.issued 2010-06-07
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20588390
dc.identifier 199840
dc.identifier.citation Opt Express, 2010, 18 (12), pp. 12630 - 12645
dc.identifier.uri http://hdl.handle.net/10161/4239
dc.description.abstract The ability of diffuse reflectance spectroscopy to extract quantitative biological composition of tissues has been used to discern tissue types in both pre-clinical and clinical cancer studies. Typically, diffuse reflectance spectroscopy systems are designed for single-point measurements. Clinically, an imaging system would provide valuable spatial information on tissue composition. While it is feasible to build a multiplexed fiber-optic probe based spectral imaging system, these systems suffer from drawbacks with respect to cost and size. To address these we developed a compact and low cost system using a broadband light source with an 8-slot filter wheel for illumination and silicon photodiodes for detection. The spectral imaging system was tested on a set of tissue mimicking liquid phantoms which yielded an optical property extraction accuracy of 6.40 +/- 7.78% for the absorption coefficient (micro(a)) and 11.37 +/- 19.62% for the wavelength-averaged reduced scattering coefficient (micro(s)').
dc.format.extent 12630 - 12645
dc.language ENG
dc.language.iso en_US en_US
dc.relation.ispartof Opt Express
dc.subject Computer Simulation
dc.subject Imaging, Three-Dimensional
dc.subject Optical Phenomena
dc.subject Phantoms, Imaging
dc.subject Spectrum Analysis
dc.title A low-cost, portable, and quantitative spectral imaging system for application to biological tissues.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-6-7 en_US
duke.description.endpage 12645 en_US
duke.description.issue 12 en_US
duke.description.startpage 12630 en_US
duke.description.volume 18 en_US
dc.relation.journal Optics Express en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20588390
pubs.issue 12
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/Initiatives
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/Initiatives/Duke Science & Society
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Global Health Institute
pubs.organisational-group /Duke/Pratt School of Engineering
pubs.organisational-group /Duke/Pratt School of Engineering/Biomedical Engineering
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Pharmacology & Cancer Biology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Radiation Oncology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.publication-status Published
pubs.volume 18
dc.identifier.eissn 1094-4087

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