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dc.contributor.author Bender, JE
dc.contributor.author Shang, AB
dc.contributor.author Moretti, EW
dc.contributor.author Yu, B
dc.contributor.author Richards, LM
dc.contributor.author Ramanujam, N
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:27:43Z
dc.date.issued 2009-12-21
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20052047
dc.identifier 192701
dc.identifier.citation Opt Express, 2009, 17 (26), pp. 23396 - 23409
dc.identifier.uri http://hdl.handle.net/10161/4243
dc.description.abstract We conducted a pilot study on 10 patients undergoing general surgery to test the feasibility of diffuse reflectance spectroscopy in the visible wavelength range as a noninvasive monitoring tool for blood loss during surgery. Ratios of raw diffuse reflectance at wavelength pairs were tested as a first-pass for estimating hemoglobin concentration. Ratios can be calculated easily and rapidly with limited post-processing, and so this can be considered a near real-time monitoring device. We found the best hemoglobin correlations were when ratios at isosbestic points of oxy- and deoxyhemoglobin were used, specifically 529/500 nm. Baseline subtraction improved correlations, specifically at 520/509 nm. These results demonstrate proof-of-concept for the ability of this noninvasive device to monitor hemoglobin concentration changes due to surgical blood loss. The 529/500 nm ratio also appears to account for variations in probe pressure, as determined from measurements on two volunteers.
dc.format.extent 23396 - 23409
dc.language ENG
dc.language.iso en_US en_US
dc.relation.ispartof Opt Express
dc.subject Biomarkers
dc.subject Blood Chemical Analysis
dc.subject Blood Loss, Surgical
dc.subject Diagnosis, Computer-Assisted
dc.subject Feasibility Studies
dc.subject Hemoglobins
dc.subject Humans
dc.subject Oxygen
dc.subject Pilot Projects
dc.subject Postoperative Hemorrhage
dc.subject Reproducibility of Results
dc.subject Sensitivity and Specificity
dc.subject Spectrophotometry, Ultraviolet
dc.title Noninvasive monitoring of tissue hemoglobin using UV-VIS diffuse reflectance spectroscopy: a pilot study.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2009-12-21 en_US
duke.description.endpage 23409 en_US
duke.description.issue 26 en_US
duke.description.startpage 23396 en_US
duke.description.volume 17 en_US
dc.relation.journal Optics Express en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20052047
pubs.issue 26
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/Initiatives
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/Initiatives/Duke Science & Society
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Global Health Institute
pubs.organisational-group /Duke/Pratt School of Engineering
pubs.organisational-group /Duke/Pratt School of Engineering/Biomedical Engineering
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Pharmacology & Cancer Biology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Anesthesiology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Anesthesiology/Anesthesiology, General, Vascular, High Risk Transplant & Critical Care
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.organisational-group /Duke/School of Nursing
pubs.organisational-group /Duke/School of Nursing/School of Nursing - Secondary Group
pubs.publication-status Published
pubs.volume 17
dc.identifier.eissn 1094-4087

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