Show simple item record

dc.contributor.author Zhao, M
dc.contributor.author Kuo, AN
dc.contributor.author Izatt, JA
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:27:44Z
dc.date.issued 2010-04-26
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20588737
dc.identifier 198210
dc.identifier.citation Opt Express, 2010, 18 (9), pp. 8923 - 8936
dc.identifier.uri http://hdl.handle.net/10161/4250
dc.description.abstract Capable of three-dimensional imaging of the cornea with micrometer-scale resolution, spectral domain-optical coherence tomography (SDOCT) offers potential advantages over Placido ring and Scheimpflug photography based systems for accurate extraction of quantitative keratometric parameters. In this work, an SDOCT scanning protocol and motion correction algorithm were implemented to minimize the effects of patient motion during data acquisition. Procedures are described for correction of image data artifacts resulting from 3D refraction of SDOCT light in the cornea and from non-idealities of the scanning system geometry performed as a pre-requisite for accurate parameter extraction. Zernike polynomial 3D reconstruction and a recursive half searching algorithm (RHSA) were implemented to extract clinical keratometric parameters including anterior and posterior radii of curvature, central cornea optical power, central corneal thickness, and thickness maps of the cornea. Accuracy and repeatability of the extracted parameters obtained using a commercial 859nm SDOCT retinal imaging system with a corneal adapter were assessed using a rigid gas permeable (RGP) contact lens as a phantom target. Extraction of these parameters was performed in vivo in 3 patients and compared to commercial Placido topography and Scheimpflug photography systems. The repeatability of SDOCT central corneal power measured in vivo was 0.18 Diopters, and the difference observed between the systems averaged 0.1 Diopters between SDOCT and Scheimpflug photography, and 0.6 Diopters between SDOCT and Placido topography.
dc.format.extent 8923 - 8936
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof Opt Express
dc.subject Artifacts
dc.subject Calibration
dc.subject Contact Lenses
dc.subject Cornea
dc.subject Humans
dc.subject Phantoms, Imaging
dc.subject Refraction, Ocular
dc.subject Reproducibility of Results
dc.subject Tomography, Optical Coherence
dc.title 3D refraction correction and extraction of clinical parameters from spectral domain optical coherence tomography of the cornea.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-4-26 en_US
duke.description.endpage 8936 en_US
duke.description.issue 9 en_US
duke.description.startpage 8923 en_US
duke.description.volume 18 en_US
dc.relation.journal Optics Express en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20588737
pubs.issue 9
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Duke Institute for Brain Sciences
pubs.organisational-group /Duke/Pratt School of Engineering
pubs.organisational-group /Duke/Pratt School of Engineering/Biomedical Engineering
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Ophthalmology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Ophthalmology/Ophthalmology, Corneal Diseases
pubs.publication-status Published
pubs.volume 18
dc.identifier.eissn 1094-4087

Files in this item

This item appears in the following Collection(s)

Show simple item record