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dc.contributor.author Appelgren, Kristie E. en_US
dc.date.accessioned 2011-06-21T17:27:53Z
dc.date.available 2011-06-21T17:27:53Z
dc.date.issued 2010 en_US
dc.identifier.citation Appelgren,Kristie E.;Nietert,Paul J.;Hulsey,Thomas C.;Hollis,Bruce W.;Wagner,Carol L.. 2010. Analyzing Adherence to Prenatal Supplement: Does Pill Count Measure Up?. International Journal of Endocrinology ( ): 631971-631971. en_US
dc.identifier.issn 1687-8337 en_US
dc.identifier.uri http://hdl.handle.net/10161/4319
dc.description.abstract Objective. To determine if adherence as measured by pill count would show a significant association with serum-based measures of adherence. Methods. Data were obtained from a prenatal vitamin D supplementation trial where subjects were stratified by race and randomized into three dosing groups: 400 (control), 2000, or 4000 IU vitamin D-3/day. One measurement of adherence was obtained via pill counts remaining compared to a novel definition for adherence using serum 25-hydroxy-vitamin D (25-OH-D) levels (absolute change in 25(OH) D over the study period and the subject's steady-state variation in their 25(OH) D levels). A multivariate logistic regression model examined whether mean percent adherence by pill count was significantly associated with the adherence measure by serum metabolite levels. Results. Subjects' mean percentage of adherence by pill count was not a significant predictor of adherence by serum metabolite levels. This finding was robust across a series of sensitivity analyses. Conclusions. Based on our novel definition of adherence, pill count was not a reliable predictor of adherence to protocol, and calls into question how adherence is measured in clinical research. Our findings have implications regarding the determination of efficacy of medications under study and offer an alternative approach to measuring adherence of long half-life supplements/medications. en_US
dc.language.iso en_US en_US
dc.publisher HINDAWI PUBLISHING CORPORATION en_US
dc.relation.isversionof doi:10.1155/2010/631971 en_US
dc.subject vitamin-d deficiency en_US
dc.subject systemic-lupus-erythematosus en_US
dc.subject rheumatoid-arthritis en_US
dc.subject cutaneous synthesis en_US
dc.subject multiple-sclerosis en_US
dc.subject plasma en_US
dc.subject 25-hydroxyvitamin-d en_US
dc.subject serum 25-hydroxyvitamin-d en_US
dc.subject binding-protein en_US
dc.subject human-pregnancy en_US
dc.subject ovarian-cancer en_US
dc.subject endocrinology & metabolism en_US
dc.title Analyzing Adherence to Prenatal Supplement: Does Pill Count Measure Up? en_US
dc.title.alternative en_US
dc.description.version Version of Record en_US
duke.date.pubdate 2010-00-00 en_US
duke.description.endpage 631971 en_US
duke.description.issue en_US
duke.description.startpage 631971 en_US
duke.description.volume en_US
dc.relation.journal International Journal of Endocrinology en_US

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