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dc.contributor.author Shertz, CA
dc.contributor.author Bastidas, RJ
dc.contributor.author Li, W
dc.contributor.author Heitman, J
dc.contributor.author Cardenas, ME
dc.coverage.spatial England
dc.date.accessioned 2011-06-21T17:29:33Z
dc.date.issued 2010
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20863387
dc.identifier 1471-2164-11-510
dc.identifier.citation BMC Genomics, 2010, 11 pp. 510 - ?
dc.identifier.uri http://hdl.handle.net/10161/4347
dc.description.abstract The nutrient-sensing Tor pathway governs cell growth and is conserved in nearly all eukaryotic organisms from unicellular yeasts to multicellular organisms, including humans. Tor is the target of the immunosuppressive drug rapamycin, which in complex with the prolyl isomerase FKBP12 inhibits Tor functions. Rapamycin is a gold standard drug for organ transplant recipients that was approved by the FDA in 1999 and is finding additional clinical indications as a chemotherapeutic and antiproliferative agent. Capitalizing on the plethora of recently sequenced genomes we have conducted comparative genomic studies to annotate the Tor pathway throughout the fungal kingdom and related unicellular opisthokonts, including Monosiga brevicollis, Salpingoeca rosetta, and Capsaspora owczarzaki.
dc.format.extent 510 - ?
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof BMC Genomics
dc.relation.isversionof 10.1186/1471-2164-11-510
dc.subject Amino Acid Sequence
dc.subject Conserved Sequence
dc.subject Evolution, Molecular
dc.subject Fungal Proteins
dc.subject Fungi
dc.subject Gene Duplication
dc.subject Genome, Fungal
dc.subject Microsporidia
dc.subject Molecular Sequence Data
dc.subject Phylogeny
dc.subject Saccharomyces cerevisiae
dc.subject Schizosaccharomyces
dc.subject Signal Transduction
dc.subject Synteny
dc.title Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdom.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US
duke.date.pubdate 2010-9-23 en_US
duke.description.endpage 510 en_US
duke.description.issue en_US
duke.description.startpage 510 en_US
duke.description.volume 11 en_US
dc.relation.journal Bmc Genomics en_US
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20863387
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Molecular Genetics and Microbiology
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Pharmacology & Cancer Biology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Infectious Diseases
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.volume 11
dc.identifier.eissn 1471-2164

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