Show simple item record DeLorenze, GN McCoy, L Tsai, AL Quesenberry, CP Rice, T Il'yasova, D Wrensch, M
dc.coverage.spatial England 2011-06-21T17:29:35Z 2010
dc.identifier 1471-2407-10-215
dc.identifier.citation BMC Cancer, 2010, 10 pp. 215 - ?
dc.description.abstract BACKGROUND: Malignant glioma is a rare cancer with poor survival. The influence of diet and antioxidant intake on glioma survival is not well understood. The current study examines the association between antioxidant intake and survival after glioma diagnosis. METHODS: Adult patients diagnosed with malignant glioma during 1991-1994 and 1997-2001 were enrolled in a population-based study. Diagnosis was confirmed by review of pathology specimens. A modified food-frequency questionnaire interview was completed by each glioma patient or a designated proxy. Intake of each food item was converted to grams consumed/day. From this nutrient database, 16 antioxidants, calcium, a total antioxidant index and 3 macronutrients were available for survival analysis. Cox regression estimated mortality hazard ratios associated with each nutrient and the antioxidant index adjusting for potential confounders. Nutrient values were categorized into tertiles. Models were stratified by histology (Grades II, III, and IV) and conducted for all (including proxy) subjects and for a subset of self-reported subjects. RESULTS: Geometric mean values for 11 fat-soluble and 6 water-soluble individual antioxidants, antioxidant index and 3 macronutrients were virtually the same when comparing all cases (n=748) to self-reported cases only (n=450). For patients diagnosed with Grade II and Grade III histology, moderate (915.8-2118.3 mcg) intake of fat-soluble lycopene was associated with poorer survival when compared to low intake (0.0-914.8 mcg), for self-reported cases only. High intake of vitamin E and moderate/high intake of secoisolariciresinol among Grade III patients indicated greater survival for all cases. In Grade IV patients, moderate/high intake of cryptoxanthin and high intake of secoisolariciresinol were associated with poorer survival among all cases. Among Grade II patients, moderate intake of water-soluble folate was associated with greater survival for all cases; high intake of vitamin C and genistein and the highest level of the antioxidant index were associated with poorer survival for all cases. CONCLUSIONS: The associations observed in our study suggest that the influence of some antioxidants on survival following a diagnosis of malignant glioma are inconsistent and vary by histology group. Further research in a large sample of glioma patients is needed to confirm/refute our results.
dc.format.extent 215 - ?
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof BMC Cancer
dc.relation.isversionof 10.1186/1471-2407-10-215
dc.subject Antioxidants
dc.subject Brain Neoplasms
dc.subject California
dc.subject Databases as Topic
dc.subject Diet
dc.subject Diet Records
dc.subject Female
dc.subject Glioma
dc.subject Humans
dc.subject Interviews as Topic
dc.subject Kaplan-Meier Estimate
dc.subject Linear Models
dc.subject Male
dc.subject Middle Aged
dc.subject Neoplasm Staging
dc.subject Proportional Hazards Models
dc.subject Risk Assessment
dc.subject Risk Factors
dc.subject SEER Program
dc.subject Time Factors
dc.subject Treatment Outcome
dc.title Daily intake of antioxidants in relation to survival among adult patients diagnosed with malignant glioma.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US 2010-5-19 en_US
duke.description.endpage 215 en_US
duke.description.issue en_US
duke.description.startpage 215 en_US
duke.description.volume 10 en_US
dc.relation.journal Bmc Cancer en_US
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Community and Family Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Community and Family Medicine/Community and Family Medicine, Prevention Research
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.volume 10
dc.identifier.eissn 1471-2407

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