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dc.contributor.author Yan, Zhen en_US
dc.date.accessioned 2011-06-21T17:30:24Z
dc.date.available 2011-06-21T17:30:24Z
dc.date.issued 2010 en_US
dc.identifier.citation Huang,Ping;Li,Shoufeng;Shao,Mengle;Qi,Qibin;Zhao,Feng;You,Jia;Mao,Ting;Li,Wenjun;Yan,Zhen;Liu,Yong. 2010. Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice. Nutrition & Metabolism 7( ): 59-59. en_US
dc.identifier.issn 1743-7075 en_US
dc.identifier.uri http://hdl.handle.net/10161/4377
dc.description.abstract Background: Calorie restriction (CR) and endurance exercise are known to attenuate obesity and improve the metabolic syndrome. The aim of this study was to directly compare the effects of CR and endurance exercise in a mouse model of diet-induced obesity and insulin resistance. Methods: Adult male C57BL/6N mice were randomly assigned and subjected to one of the six interventions for 8 weeks: low-fat diet (LC, 10% fat), low-fat diet with 30% calorie restriction (LR), high-fat diet (HC, 60% fat), high-fat diet with 30% calorie restriction (HR), high-fat diet with voluntary running exercise (HE), and high-fat diet with a combination of 30% calorie restriction and exercise (HRE). The impacts of the interventions were assessed by comprehensive metabolic analyses and pro-inflammatory cytokine gene expression. Results: Endurance exercise significantly attenuated high-fat diet-induced obesity. CR dramatically prevented high-fat diet-induced metabolic abnormalities. A combination of CR and endurance exercise further reduced obesity and insulin resistance under the condition of high-fat diet. CR and endurance exercise each potently suppressed the expression of inflammatory cytokines in white adipose tissues with additive effects when combined, but the effects of diet and exercise interventions in the liver were moderate to minimal. Conclusions: CR and endurance exercise share a potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance. en_US
dc.language.iso en_US en_US
dc.publisher BIOMED CENTRAL LTD en_US
dc.relation.isversionof doi:10.1186/1743-7075-7-59 en_US
dc.subject weight-loss program en_US
dc.subject polyunsaturated fatty-acids en_US
dc.subject type-2 en_US
dc.subject diabetes-mellitus en_US
dc.subject c-reactive protein en_US
dc.subject postmenopausal women en_US
dc.subject metabolic en_US
dc.subject syndrome en_US
dc.subject macrophage infiltration en_US
dc.subject cytokine production en_US
dc.subject skeletal-muscle en_US
dc.subject body-weight en_US
dc.subject nutrition & dietetics en_US
dc.title Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice en_US
dc.title.alternative en_US
dc.description.version Version of Record en_US
duke.date.pubdate 2010-7-16 en_US
duke.description.endpage 59 en_US
duke.description.issue en_US
duke.description.startpage 59 en_US
duke.description.volume 7 en_US
dc.relation.journal Nutrition & Metabolism en_US

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